THE EFFECT OF THYMUS MIGRICUSON ISOTONIC CONTRACTION INDUCED BY ACETYLCHOLINE ON MALE RATS ILEUM

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HEJAZIAN H.; GOLZAR M.

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Paper Information

Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2016 | Volume:24 | Issue:1 Page(s): 35-42

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Title

THE EFFECT OF THYMUS MIGRICUSON ISOTONIC CONTRACTION INDUCED BY ACETYLCHOLINE ON MALE RATS ILEUM

Author(s)

HEJAZIAN H. | GOLZAR M. | Issue Writer Certificate

Keywords

THYMUS MIGRICUSESSENCEQ1

SPASMOLYTHICQ1

ACETYLCHOLINEQ1

ILEUMQ1

Abstract

Introduction: Herbal plants have been usedfor the treatment of different abnormalities such as spasm disorders. Some of the seplants have gastro intestinal property. One of these herbs in iranian traditional medicine is Thymus migricus which usedfor antispasmodic activity and its effect spresent in essential oil. The present study was designed to find out the effects of THYMUS MIGRICUSESSENCE on mechanicalactivity of the isolated rat’s ILEUM.Materials & methods: In this study, forevaluation of SPASMOLYTHIC property ofessense, different doses of the solution wereadded to organ bath after ACETYLCHOLINE (Ach) with concentration of 10-4 molar (M) and for assessment of its antispasmodic, different doses of the solution were addedto the organ bath before Ach withconcentration of 10-6upto 10-3 M, thenisotonic contraction of ILEUM wererecorded in three groups of control, test and shamthrough an isolated tissue chamber inan organ bath by using isotonic transducerand oscillographic device.Findings: The results from different concentration of THYMUS MIGRICUSESSENCEon Ach 10-4 M showed that concentration of 50 ng/ml of essense and higher was reduced to 95% of Ach induced contraction which is significant (P<0.05).Discussion & Conclusions: THYMUS MIGRICUSESSENCE hasspasmolythic and antispasmodic property. these effects may be produced by Thymol which is present inits essence and reduced calcium activity and release by sarcoplasmic reticulum.

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APA: Copy

HEJAZIAN, H., & GOLZAR, M.. (2016). THE EFFECT OF THYMUS MIGRICUSON ISOTONIC CONTRACTION INDUCED BY ACETYLCHOLINE ON MALE RATS ILEUM. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 24(1), 35-42. SID. https://sid.ir/paper/90141/en

Vancouver: Copy

HEJAZIAN H., GOLZAR M.. THE EFFECT OF THYMUS MIGRICUSON ISOTONIC CONTRACTION INDUCED BY ACETYLCHOLINE ON MALE RATS ILEUM. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;24(1):35-42. Available from: https://sid.ir/paper/90141/en

IEEE: Copy

H. HEJAZIAN, and M. GOLZAR, “THE EFFECT OF THYMUS MIGRICUSON ISOTONIC CONTRACTION INDUCED BY ACETYLCHOLINE ON MALE RATS ILEUM,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 1, pp. 35–42, 2016, [Online]. Available: https://sid.ir/paper/90141/en

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