STUDY OF THE EFFECT OF INTRAPERITONEAL (I.P) INJECTION OF NALOXONE ON METABOTROPIC GABAB RECEPTOR AGENTS INTO MESENCEPHALIC CUNEIFORMIS NUCLEUS (CNF) OF RAT

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BAKHSHESH M.; REZVANIPOUR M.; SHEYBANI VAHID

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Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2006 | Volume:14 | Issue:2 Page(s): 8-16

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Title

STUDY OF THE EFFECT OF INTRAPERITONEAL (I.P) INJECTION OF NALOXONE ON METABOTROPIC GABAB RECEPTOR AGENTS INTO MESENCEPHALIC CUNEIFORMIS NUCLEUS (CNF) OF RAT

Author(s)

BAKHSHESH M. | REZVANIPOUR M. | SHEYBANI VAHID | Issue Writer Certificate

Keywords

NALOXONEQ3

GABAB RECEPTORQ3

CUNEIFORMIS NUCLEUSQ3

NOCICEPTIONQ3

Abstract

Introduction: There are several evidences which prove CUNEIFORMIS NUCLEUS involvement in NOCICEPTION and possible role of opioid modulation of pain transmission from periphery to the cord and other higher nervous centers was the most interest of this study to be justified.Material & methods: In the present study, the effect of intra cuneiformis microinjection of GABAB receptor agonist (-(-) Baclofen) and antagonists (CGP35348) on morphine-induced antinociception in rat were investigated. Findings: Microinjection of morphine (10mg/0.5ml/rat) or different doses of Baclofen (.25, .5 &1μg per rat) had antinociception in the both, first and second phases of the formalin test. The response induced by morphine or baclofen in both phases was reduced by CGP35348. The response induced by combination of microinjection of baclofen (1mg per rat) and intraperitoneal (i.p) injection of NALOXONE in both phases was reduced in comparison to saline or baclofen (1mg per rat) alone.Microinjection of CGP35348 alone produced antinociception in the first phase of the formalin test. Morphine in combination with different doses of baclofen did not elicit potentialities in both phases, while CGP35348 in acute phase elicited potentialities.Conclusion: It may be concluded that Cnf GABAB receptor via opioid receptor, induced antinociception in the formalin test.

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APA: Copy

BAKHSHESH, M., REZVANIPOUR, M., & SHEYBANI, VAHID. (2006). STUDY OF THE EFFECT OF INTRAPERITONEAL (I.P) INJECTION OF NALOXONE ON METABOTROPIC GABA_B RECEPTOR AGENTS INTO MESENCEPHALIC CUNEIFORMIS NUCLEUS (CNF) OF RAT. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 14(2), 8-16. SID. https://sid.ir/paper/90294/en

Vancouver: Copy

BAKHSHESH M., REZVANIPOUR M., SHEYBANI VAHID. STUDY OF THE EFFECT OF INTRAPERITONEAL (I.P) INJECTION OF NALOXONE ON METABOTROPIC GABA_B RECEPTOR AGENTS INTO MESENCEPHALIC CUNEIFORMIS NUCLEUS (CNF) OF RAT. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;14(2):8-16. Available from: https://sid.ir/paper/90294/en

IEEE: Copy

M. BAKHSHESH, M. REZVANIPOUR, and VAHID SHEYBANI, “STUDY OF THE EFFECT OF INTRAPERITONEAL (I.P) INJECTION OF NALOXONE ON METABOTROPIC GABA_B RECEPTOR AGENTS INTO MESENCEPHALIC CUNEIFORMIS NUCLEUS (CNF) OF RAT,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 14, no. 2, pp. 8–16, 2006, [Online]. Available: https://sid.ir/paper/90294/en

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