ANTISPASMODIC ACTIVITY OF ALLIUM CEPA PEEL HYDROALCOHOLIC EXTRACT ON RAT ILEUM

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHARIB NASERI MOHAMMAD KAZEM; YAHYAVI H.; ARABIAN M.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Seminar Paper

Paper Information

Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2007 | Issue:18

Download Full-Text

View:

152

Download:

Information Seminar Paper

Title

ANTISPASMODIC ACTIVITY OF ALLIUM CEPA PEEL HYDROALCOHOLIC EXTRACT ON RAT ILEUM

Author(s)

GHARIB NASERI MOHAMMAD KAZEM | YAHYAVI H. | ARABIAN M.

Keywords

Not Registered.

Abstract

Introduction: Onion (Allium cepa) from Liliaceae has antioxidant and antihypertensive activities. The aim of present study was to investigate the antispasmodic effect of onion peel on rat ileum contractility.Methods: Onion peel powder was extracted by maceration in 70% alcohol for 72 h. A terminal portion of male rat ileum was dissected and its contractions were recorded isotonically in an organ bath containing Tyrode solution (37 ؛C) under 1g tension.Results: Extract cumulative concentrations (0.1, 0.2, 0.4 mg/ml) reduced the ileum contraction induced by KCl (60 mM) and by carbachol (10μM) dose-dependently (P<0.0001). The antispasmodic effect of extract was not reduced by tissue incubation with propranolol (1μM), naloxone (1μM), L-NAME (100μM), glibenclamide (10μM) and neither by tetraethylammonium (1mM). In Ca2+-free with high K+ (60mM) Tyrode solution, extract reduced the ileum contractions induced by CaCl2 dose-dependently (P<0.05). Conclusion: Onion peel extract inhibits ileum contractions without involving β-adrenoceptors, opioid receptors, NO synthesis, and without potassium channels activation. It seems that the voltage dependent calcium channels are involved in the spasmolytic effect of the extract.

Cites

No record.

References

No record.

Cite

APA: Copy

GHARIB NASERI, MOHAMMAD KAZEM, YAHYAVI, H., & ARABIAN, M.. (2007). ANTISPASMODIC ACTIVITY OF ALLIUM CEPA PEEL HYDROALCOHOLIC EXTRACT ON RAT ILEUM. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/904873/en

Vancouver: Copy

GHARIB NASERI MOHAMMAD KAZEM, YAHYAVI H., ARABIAN M.. ANTISPASMODIC ACTIVITY OF ALLIUM CEPA PEEL HYDROALCOHOLIC EXTRACT ON RAT ILEUM. 2007. Available from: https://sid.ir/paper/904873/en

IEEE: Copy

MOHAMMAD KAZEM GHARIB NASERI, H. YAHYAVI, and M. ARABIAN, “ANTISPASMODIC ACTIVITY OF ALLIUM CEPA PEEL HYDROALCOHOLIC EXTRACT ON RAT ILEUM,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2007, [Online]. Available: https://sid.ir/paper/904873/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops