A NEW AND EFFECTIVE METHOD FOR PREPARATION OF ALPRAZOLAM

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MOHANAZADEH FARAJOLLAH; HAJINASIRI RAHIMEH; HOSSEINI SAYED MOHAMMAD

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Seminar Paper

Paper Information

Seminar: IRANIAN SEMINAR OF ORGANIC CHEMISTRY
Year:2012 | Issue:19

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Title

A NEW AND EFFECTIVE METHOD FOR PREPARATION OF ALPRAZOLAM

Author(s)

MOHANAZADEH FARAJOLLAH | HAJINASIRI RAHIMEH | HOSSEINI SAYED MOHAMMAD

Keywords

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Abstract

BENZODIAZEPINES ARE KNOWN AS DRUGS AFFECTING THE CENTRAL NERVOUS SYSTEM [1, 2]. ALPRAZOLAM IS ONE OF THE NEWEST AND MOST EFFECTIVE DRUGS IN THIS FAMILY. [3].CONVENTIONAL METHODS FOR PREPARING THIS COMPOUND INCLUDE THE USE OF TOXIC SUBSTANCES SUCH AS PYRIDINE AND P2S5 [4].IN THIS STUDY, A NEW METHOD FOR THE PREPARATION OF ALPRAZOLAM FROM CHLORDIAZEPOXIDE HAS BEEN DEVELOPED. CHLORDIAZEPOXIDE IS CHEAP AND AVAILABLE IN THE INDUSTRIAL SCALE. ALPRAZOLAM WAS PREPARED IN THREE STEPS. REACTION CONDITIONS WERE OPTIMIZED FOR EACH STAGE. CHLORDIAZEPOXIDE WAS CONVERTED TO ITS NITROSO DERIVATIVE BY SODIUM NITRITE. ALPRAZOLAM OXIDE WAS OBTAINED BY REACTION OF NITROSO COMPOUND WITH ACETYL HYDRAZINE. IN A DEOXYGENATION REACTION BY PHOSPHORUS TRICHLORIDE ALPRAZOLAM OXIDE WAS CONVERTED TO ALPRAZOLAM. THIS COMPOUND WAS TESTED ON USP 31. IT PASSED ALL OF THE TESTS.

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APA: Copy

MOHANAZADEH, FARAJOLLAH, HAJINASIRI, RAHIMEH, & HOSSEINI, SAYED MOHAMMAD. (2012). A NEW AND EFFECTIVE METHOD FOR PREPARATION OF ALPRAZOLAM. IRANIAN SEMINAR OF ORGANIC CHEMISTRY. SID. https://sid.ir/paper/909495/en

Vancouver: Copy

MOHANAZADEH FARAJOLLAH, HAJINASIRI RAHIMEH, HOSSEINI SAYED MOHAMMAD. A NEW AND EFFECTIVE METHOD FOR PREPARATION OF ALPRAZOLAM. 2012. Available from: https://sid.ir/paper/909495/en

IEEE: Copy

FARAJOLLAH MOHANAZADEH, RAHIMEH HAJINASIRI, and SAYED MOHAMMAD HOSSEINI, “A NEW AND EFFECTIVE METHOD FOR PREPARATION OF ALPRAZOLAM,” presented at the IRANIAN SEMINAR OF ORGANIC CHEMISTRY. 2012, [Online]. Available: https://sid.ir/paper/909495/en

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