HEAD SPACE SOLID-PHASE MICROEXTRACTION OF METHADONE PRIOR TO DETERMINATION BY GAS CHROMATOGRAPHY-FLAME IONIZATION DETECTOR

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DALALI NASSER; PARANDI KHATEREH

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Seminar Paper

Paper Information

Seminar: IRANIAN SEMINAR OF ANALYTICAL CHEMISTRY
Year:2014 | Issue:20

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Title

HEAD SPACE SOLID-PHASE MICROEXTRACTION OF METHADONE PRIOR TO DETERMINATION BY GAS CHROMATOGRAPHY-FLAME IONIZATION DETECTOR

Author(s)

DALALI NASSER | PARANDI KHATEREH | Issue Writer Certificate

Keywords

SOLID PHASE MICROEXTRACTION

IONIC LIQUID

METHADONE

Abstract

SOLID PHASE MICROEXTRACTION AS A SOLVENT FREE SAMPLE PREPARATION TECHNIQUE INVENTED BY PAWLISZYN AND CO-WORKERS IN 1990 [1], HAS ATTRACTED THE EYE BALL OF MANY RESEARCHERS IN DIFFERENT FIELDS DURING THE PAST FEW YEARS. ONE OF THE MAIN EFFORTS IS DEVOTED TO THE INTRODUCTION AND APPLICATION OF NOVEL FIBRE COATINGS. IONIC LIQUIDS IS ONE OF THE CONCERNED MATERIALS FOR THIS PURPOSE [2].METHADONE IS A SYNTHETIC OPIATE. IN MANY COUNTRIES IT IS USED FOR SUBSTITUTION THERAPY OF HEROIN ADDICTION. AS A RESULT OF THE VERY LIBERAL PRESCRIPTION PRACTICE IT GETS INTO THE DRUG SCENE AND IS ABUSED ALSO BY OTHER PERSONS LEADING TO SEVERE INTOXICATIONS AND METHADONE FATALITIES [3]. METHADONE WAS FIRST USED TO TREAT HEROIN ADDICTS IN 1965 IN UNITED STATES AND IN 1966 IN EUROPE (SWEDEN), AND IT IS STILL USED IN IRAN AS ONE OF THE MAIN APPLICABLE THERAPY SUBSTITUENT.HENCE ITS MONITORING IN BIOLOGICAL OR PHARMACEUTICAL SAMPLES IS IMPORTANT CONSIDERING THE DRUG ABUSE AS WELL AS TREATMENT PROCESSES. IN THE PRESENT WORK A NEWLY SYNTHESIZED IONIC LIQUID ABBREVIATED AS (ET)2EMIMNTF2, IS USED AS COATING OF A STAINLESS STEEL WIRE (METAL FIBRE) FOR EXTRACTION/PRECONCENTRATION OF METHADONE PRIOR TO ITS ANALYSIS BY GAS CHROMATOGRAPHY. THE INFLUENCE OF EXPERIMENTAL PARAMETERS SUCH AS INITIAL SAMPLE BASICITY, AGITATION RATE, TEMPERATURE, SALT CONCENTRATION, AND EQUILIBRIUM TIME ON THE EXTRACTION EFFICIENCY WAS STUDIED AND OPTIMIZED AS 3M NAOH, 700 RPM, 50OC, 30% (W/V) NACL, AND 30 MIN, RESPECTIVELY. UNDER OPTIMUM CONDITIONS, THE CALIBRATION GRAPH WAS LINEAR IN THE RANGE OF 10-50 AND 200-1000 NG ML-1. THE DETECTION LIMIT AND THE RELATIVE STANDARD DEVIATION WERE OBTAINED AS 1.29 NG ML-1 (3SB/M, N=6), AND 5.6% (N=6, C=500 NG ML-1), RESPECTIVELY. THE TECHNIQUE WAS SUCCESSFULLY APPLIED FOR BLOOD SAMPLE.

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APA: Copy

DALALI, NASSER, & PARANDI, KHATEREH. (2014). HEAD SPACE SOLID-PHASE MICROEXTRACTION OF METHADONE PRIOR TO DETERMINATION BY GAS CHROMATOGRAPHY-FLAME IONIZATION DETECTOR. IRANIAN SEMINAR OF ANALYTICAL CHEMISTRY. SID. https://sid.ir/paper/911792/en

Vancouver: Copy

DALALI NASSER, PARANDI KHATEREH. HEAD SPACE SOLID-PHASE MICROEXTRACTION OF METHADONE PRIOR TO DETERMINATION BY GAS CHROMATOGRAPHY-FLAME IONIZATION DETECTOR. 2014. Available from: https://sid.ir/paper/911792/en

IEEE: Copy

NASSER DALALI, and KHATEREH PARANDI, “HEAD SPACE SOLID-PHASE MICROEXTRACTION OF METHADONE PRIOR TO DETERMINATION BY GAS CHROMATOGRAPHY-FLAME IONIZATION DETECTOR,” presented at the IRANIAN SEMINAR OF ANALYTICAL CHEMISTRY. 2014, [Online]. Available: https://sid.ir/paper/911792/en

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