RESPONSE SURFACE METHODOLOGY IN THE OPTIMIZATION OF CHITOSAN NANOPARTICLES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

DARIJANI M.; HOSSEINI M.; Shahavi M.H.; JAHANSHAHI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Seminar Paper

Paper Information

Seminar: INTERNATIONAL COMPREHENSIVE COMPETITION CONFERENCE ON ENGINEERING SCIENCE IN IRAN
Year:2016 | Issue:1

Download Full-Text

View:

340

Download:

119

Information Seminar Paper

Title

RESPONSE SURFACE METHODOLOGY IN THE OPTIMIZATION OF CHITOSAN NANOPARTICLES

Author(s)

DARIJANI M. | HOSSEINI M. | Shahavi M.H. | JAHANSHAHI M.

Keywords

CHITOSAN

NANOPARTICLES

RESPONSE SURFACE METHODOLOGY

Abstract

THE OBJECTIVES WERE TO INVESTIGATE THE EFFECTS OF FORMULATION VARIABLES ON THE ENCAPSULATION EFFICIENCY OF DRUG AND TO OPTIMIZE THE FORMULATION OF CHITOSAN NANOPARTICLES LOADED WITH ELLAGIC ACID FOR ENCAPSULATION EFFICIENCY USING RESPONSE SURFACE METHODOLOGY. CHITOSAN NANOPARTICLES WERE PREPARED BY IONIC GELATION METHOD USING SODIUM TRIPOLYPHOSPHATE AS A GELATING AGENT. A CENTRAL COMPOSITE DESIGN WAS USED TO EVALUATE AND OPTIMIZE THE EFFECT OF PREPARATION VARIABLES, DRUG CONCENTRATION (A), CHITOSAN CONCENTRATION (B), TPP CONCENTRATION (C) ON ENCAPSULATION EFFICIENCY (R). THE SUITABILITY OF THE PROPOSED QUADRATIC MODEL WAS PROVED WITH HIGH CORRELATION COEFFICIENT (R2=0.9993), INDICATING THE SUCCESS OF RSM IN OPTIMIZATION OF OPERATING PARAMETERS IN THE PREDICTION OF ENCAPSULATION EFFICIENCY. THE ADEQUATE PRECISION IS 83.136, WHICH INDICATES AN ADEQUATE SIGNAL, HENCE THIS MODEL COULD BE USED TO NAVIGATE THE RESPONSE SURFACE DESIGN SPACE. THE OPTIMIZED EXPERIMENTAL VARIABLES FOR ENCAPSULATION EFFICIENCY DETERMINED IN THIS STUDY WERE FOUND AS ELLAGIC ACID (0.3 MG/ML), CHITOSAN (3 MG/ML) AND TPP (0.05 MG/ML) CONCENTRATIONS. THE TPP CONCENTRATION WAS THE MOST INFLUENTIAL FACTOR THAT AFFECTED ON DRUG ENCAPSULATION EFFICIENCY.

Cites

No record.

References

No record.

Cite

APA: Copy

DARIJANI, M., HOSSEINI, M., Shahavi, M.H., & JAHANSHAHI, M.. (2016). RESPONSE SURFACE METHODOLOGY IN THE OPTIMIZATION OF CHITOSAN NANOPARTICLES. INTERNATIONAL COMPREHENSIVE COMPETITION CONFERENCE ON ENGINEERING SCIENCE IN IRAN. SID. https://sid.ir/paper/922587/en

Vancouver: Copy

DARIJANI M., HOSSEINI M., Shahavi M.H., JAHANSHAHI M.. RESPONSE SURFACE METHODOLOGY IN THE OPTIMIZATION OF CHITOSAN NANOPARTICLES. 2016. Available from: https://sid.ir/paper/922587/en

IEEE: Copy

M. DARIJANI, M. HOSSEINI, M.H. Shahavi, and M. JAHANSHAHI, “RESPONSE SURFACE METHODOLOGY IN THE OPTIMIZATION OF CHITOSAN NANOPARTICLES,” presented at the INTERNATIONAL COMPREHENSIVE COMPETITION CONFERENCE ON ENGINEERING SCIENCE IN IRAN. 2016, [Online]. Available: https://sid.ir/paper/922587/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops