Effect of 12-week resistance training on Mafa expression in pancreas tissue and serum insulin level in type 2 diabetic rats

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HASANPOUR MORTEZA; Farajtabar Behrestaq Saqqa; ASKARI BABISAN

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Journal Paper

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Journal: Medical Journal of Mashhad University of Medical Sciences Year:2020 | Volume:63 | Issue:1 Page(s): 2267-2976

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Title

Effect of 12-week resistance training on Mafa expression in pancreas tissue and serum insulin level in type 2 diabetic rats

Author(s)

HASANPOUR MORTEZA | Farajtabar Behrestaq Saqqa | ASKARI BABISAN | Issue Writer Certificate

Keywords

Type 2 diabetes

Mafa expression

serum Insulin

Resistance training

Abstract

Introduction: Increased Mafa expression with increased insulin secretion from pancreatic beta cells and consequent improvement in glycemic profile in type 2 diabetic patients. This study aimed to determine the effect of resistance on Mafa expression in pancreas tissue, glucose and insulin in Type 2 diabetes rats. Materials and Methods: The statistical population consisted of all male Wistar rats of the pastor inistitue of Iran, among which 14 were male rat 10 weeks old weighting 220 ± 20 g. Type 2 diabetes induced by Intraperitoneal injection of nicotinamid + STZ. Then rats divided randomly into resistance (6 weeks, 5 times/weekly, n=7) and control (n=7) groups. Fasting glucose, serum Insulin and Mafa expression in Pancreas tissue of both groups were measured after lasted exercise and compared between 2 groups by independent T test. Results: Resistance training significantly reduced fasting glucose and significantly increased serum Insulin levels compared with the control group. Resistance training also increased Mafa expression in pancreatic tissue( p>0/0001). Conclusion: Based on these data, increased serum Insulin in response to Resistance training in T2D rats may be attributed with increased Mafa expression in pancreas tissue.

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APA: Copy

HASANPOUR, MORTEZA, Farajtabar Behrestaq, Saqqa, & ASKARI, BABISAN. (2020). Effect of 12-week resistance training on Mafa expression in pancreas tissue and serum insulin level in type 2 diabetic rats. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 63(1 ), 2267-2976. SID. https://sid.ir/paper/950122/en

Vancouver: Copy

HASANPOUR MORTEZA, Farajtabar Behrestaq Saqqa, ASKARI BABISAN. Effect of 12-week resistance training on Mafa expression in pancreas tissue and serum insulin level in type 2 diabetic rats. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;63(1 ):2267-2976. Available from: https://sid.ir/paper/950122/en

IEEE: Copy

MORTEZA HASANPOUR, Saqqa Farajtabar Behrestaq, and BABISAN ASKARI, “Effect of 12-week resistance training on Mafa expression in pancreas tissue and serum insulin level in type 2 diabetic rats,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 63, no. 1 , pp. 2267–2976, 2020, [Online]. Available: https://sid.ir/paper/950122/en

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