EPIGENETIC MECHANISMS AND THEIR EFFECTS ON CANCER INCIDENCE AND TREATMENT: A REVIEW STUDY

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HOSHYAR REYHANE; BOOMI GHOOCHANE ATIGH MASOOMEH

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Journal: Journal of Birjand University of Medical Sciences Year:2015 | Volume:22 | Issue:2 Page(s): 83-93

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Information Journal Paper

Title

EPIGENETIC MECHANISMS AND THEIR EFFECTS ON CANCER INCIDENCE AND TREATMENT: A REVIEW STUDY

Author(s)

HOSHYAR REYHANE | BOOMI GHOOCHANE ATIGH MASOOMEH | Issue Writer Certificate

Keywords

EPIGENETICQ2

CANCERQ2

DNAQ3

HISTONEQ2

Abstract

Both genetic and EPIGENETIC changes are effective in CANCER incidence and development. EPIGENETIC processes are alternations of DNA and HISTONEs conformations, chromatin remodeling, DNA methylation, post-translational modifications of HISTONEs and microRNAs patterns which are associated with genes expression or inhibition of them in cells. Some of reversible EPIGENETIC changes such as DNA and histcone conformation alternations related to drug interaction, stabilization of telomeric quadruplex sequences, DNA hypermethylation and HISTONE acetylation and phosphorylation have been recognized as promising novel therapeutic targets in various CANCERs. In the present review, molecular mechanisms of EPIGENETICs, EPIGENETIC changes in tumors, and EPIGENETIC based treatments are discussed.

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APA: Copy

HOSHYAR, REYHANE, & BOOMI GHOOCHANE ATIGH, MASOOMEH. (2015). EPIGENETIC MECHANISMS AND THEIR EFFECTS ON CANCER INCIDENCE AND TREATMENT: A REVIEW STUDY. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 22(2), 83-93. SID. https://sid.ir/paper/95364/en

Vancouver: Copy

HOSHYAR REYHANE, BOOMI GHOOCHANE ATIGH MASOOMEH. EPIGENETIC MECHANISMS AND THEIR EFFECTS ON CANCER INCIDENCE AND TREATMENT: A REVIEW STUDY. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;22(2):83-93. Available from: https://sid.ir/paper/95364/en

IEEE: Copy

REYHANE HOSHYAR, and MASOOMEH BOOMI GHOOCHANE ATIGH, “EPIGENETIC MECHANISMS AND THEIR EFFECTS ON CANCER INCIDENCE AND TREATMENT: A REVIEW STUDY,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 2, pp. 83–93, 2015, [Online]. Available: https://sid.ir/paper/95364/en

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