COMPARISON OF EXTRA-AMNIOTIC NORMAL SALINE INFUSION PLUS HYDROCORTISONE VERSUS PROSTAGLANDIN E2 SUPPOSITORY FOR PREGNANCY TERMINATION

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KESHAVARZI FARAHNAZ; NANKALI ANISODOWLEH; REZAEI MANSOUR; FAKHERI TARAVAT; JALILIAN NASRIN; MOHAMMADI NOOSHIN; LASHANI NARGES; KHOSHAY AHMAD

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Journal: Journal of Birjand University of Medical Sciences Year:2012 | Volume:19 | Issue:2 (51) Page(s): 132-139

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Title

COMPARISON OF EXTRA-AMNIOTIC NORMAL SALINE INFUSION PLUS HYDROCORTISONE VERSUS PROSTAGLANDIN E2 SUPPOSITORY FOR PREGNANCY TERMINATION

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Keywords

EXTRA-AMNIOTIC SALINE INFUSIONQ2

HYDROCORTISONE (EASI+H)Q3

PROSTAGLANDIN E2 (PGE2)Q3

CERVICAL RIPENINGQ2

PREGNANCY TERMINATIONQ3

Abstract

Background and Aim: PREGNANCY TERMINATION before onset of labor is one of the midwifery problems. The aim of the present study was to compare extra-amniotic normal saline infusion plus hydrocortisone effect versus prostaglandin E2 suppository for CERVICAL RIPENING and second- trimester PREGNANCY TERMINATION.Materials and Methods: This randomized clinical-trial study was performed on 50 pregnant women with gestation age of 14 to 28 weeks and Bishop’s Score£2 who required PREGNANCY TERMINATION for fetal indications. Half of the cases received extra-amniotic normal saline infusion plus 100 mg hydrocortisone (EASI+H) and the other half received two doses of 3mg prostaglandin E2 suppository every 4 hours. Six hours later, induction of labor was started by means of a high dose of Oxytocin according to of Alabama University Protocol for Mid-trimester Abortion. The obtained data was analyzed by using statistical methods Chi-square, Fisher and T-test.Results: There were no differences between the two groups regarding maternal age, parity, gestational age, Primary Bishop, s Score and indication of PREGNANCY TERMINATION. In the EASI+H group, the mean interval between initiation of labor induction and fetal expulsion was 23.04±4.47 hours and in PGE2 group was 28.65±2.87 hours (P=0.001). The success rate in the EASI+H group was 100% and in PGE2 group 80% (P=0.04). Complications such as fever, nausea, vomiting, diarrhea, increase of blood pressure and need to curettage in PGE2 group were statistically and significantly more abundant.Conclusion: Extra-amniotic normal saline infusion plus hydrocortisone is an effective and safe method that is suggested for CERVICAL RIPENING and second- trimester PREGNANCY TERMINATION.

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APA: Copy

KESHAVARZI, FARAHNAZ, NANKALI, ANISODOWLEH, REZAEI, MANSOUR, FAKHERI, TARAVAT, JALILIAN, NASRIN, MOHAMMADI, NOOSHIN, LASHANI, NARGES, & KHOSHAY, AHMAD. (2012). COMPARISON OF EXTRA-AMNIOTIC NORMAL SALINE INFUSION PLUS HYDROCORTISONE VERSUS PROSTAGLANDIN E₂ SUPPOSITORY FOR PREGNANCY TERMINATION. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 19(2 (51)), 132-139. SID. https://sid.ir/paper/95412/en

Vancouver: Copy

KESHAVARZI FARAHNAZ, NANKALI ANISODOWLEH, REZAEI MANSOUR, FAKHERI TARAVAT, JALILIAN NASRIN, MOHAMMADI NOOSHIN, LASHANI NARGES, KHOSHAY AHMAD. COMPARISON OF EXTRA-AMNIOTIC NORMAL SALINE INFUSION PLUS HYDROCORTISONE VERSUS PROSTAGLANDIN E₂ SUPPOSITORY FOR PREGNANCY TERMINATION. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;19(2 (51)):132-139. Available from: https://sid.ir/paper/95412/en

IEEE: Copy

FARAHNAZ KESHAVARZI, ANISODOWLEH NANKALI, MANSOUR REZAEI, TARAVAT FAKHERI, NASRIN JALILIAN, NOOSHIN MOHAMMADI, NARGES LASHANI, and AHMAD KHOSHAY, “COMPARISON OF EXTRA-AMNIOTIC NORMAL SALINE INFUSION PLUS HYDROCORTISONE VERSUS PROSTAGLANDIN E₂ SUPPOSITORY FOR PREGNANCY TERMINATION,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 19, no. 2 (51), pp. 132–139, 2012, [Online]. Available: https://sid.ir/paper/95412/en

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