Protective Effect of Aerobic Training along with Resveratrol on the Expression of some Atrophic Biomarkers of Cardiomyocytes in Diabetic rats

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Esmailee Bentollhoda; ABDI AHMAD; FARZANEGI PARVIN; ABBASSI DALOII ASIEH

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Journal: Journal of Neyshabur University of Medical Sciences Year:2019 | Volume:7 | Issue:3 (24) Page(s): 27-37

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Information Journal Paper

Title

Protective Effect of Aerobic Training along with Resveratrol on the Expression of some Atrophic Biomarkers of Cardiomyocytes in Diabetic rats

Author(s)

Esmailee Bentollhoda | ABDI AHMAD | FARZANEGI PARVIN | ABBASSI DALOII ASIEH | Issue Writer Certificate

Keywords

Exercise

herbs

FOXO3a

MuRF1

Diabetic rats

Abstract

Introduction The aim of the present study was to examine the effect of aerobic training along with resveratrol on cardiac expression of FOXO3a and MuRF1 in diabetic male rats. Materials and Methods Forty Wistar male rats were randomly classified into Control-Normal (CN), Diabetes Mellitus (DM), Resveratrol-Diabetes Mellitus (RDM), Training-Diabetes Mellitus (TDM) and Training-Resveratrol-Diabetes Mellitus (TRDM) groups. Training groups have performed a running program on a motor-driven treadmill for eight weeks. Resveratrol (20 mg/kg) was injected into the RDM and TRDM groups. Forty-eight hours after the last training session, rats were sacrificed; hearts were excised and immediately frozen in liquid nitrogen and stored at-80 ° C for measuring the indexes. Statistical analysis was performed using a one-way analysis of variance, and significance was accepted at p ≤ 0. 05. Results The results of this study showed a reduction in the expression of FOXO3a (p=0. 0001) and MuRF1 (p=0. 0001) cardiomyocytes in the TDM group compared to the DM group. The expression of FOXO3a (p=0. 045) and MuRF1 (p=0. 037) in the RDM group was significantly decreased in comparison to the DM group. Also, the expression of FOXO3a (p=0. 026) and MuRF1 (p=0. 007) cardiomyocytes in the TRDM groups also had a significant decrease compared to the DM group. Conclusion Our findings show that an aerobic training with and without resveratrol maybe inhibits atrophic biomarkers of cardiomyocytes in diabetic male rats.

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APA: Copy

Esmailee, Bentollhoda, ABDI, AHMAD, FARZANEGI, PARVIN, & ABBASSI DALOII, ASIEH. (2019). Protective Effect of Aerobic Training along with Resveratrol on the Expression of some Atrophic Biomarkers of Cardiomyocytes in Diabetic rats. JOURNAL OF NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES, 7(3 (24) ), 27-37. SID. https://sid.ir/paper/954243/en

Vancouver: Copy

Esmailee Bentollhoda, ABDI AHMAD, FARZANEGI PARVIN, ABBASSI DALOII ASIEH. Protective Effect of Aerobic Training along with Resveratrol on the Expression of some Atrophic Biomarkers of Cardiomyocytes in Diabetic rats. JOURNAL OF NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;7(3 (24) ):27-37. Available from: https://sid.ir/paper/954243/en

IEEE: Copy

Bentollhoda Esmailee, AHMAD ABDI, PARVIN FARZANEGI, and ASIEH ABBASSI DALOII, “Protective Effect of Aerobic Training along with Resveratrol on the Expression of some Atrophic Biomarkers of Cardiomyocytes in Diabetic rats,” JOURNAL OF NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES, vol. 7, no. 3 (24) , pp. 27–37, 2019, [Online]. Available: https://sid.ir/paper/954243/en

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