COMPARISON OF ANTIOXIDANT PROPERTIES OF N- ACETYLCYSTEINE AND VITAMINS E AND C ON DIAZINON-INDUCED OXIDATIVE STRESS IN RAT SPLEEN

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HEYDARI JAVAD; JAFARI MAHVASH; KHAZAIE SAEED

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Journal: Journal of Birjand University of Medical Sciences Year:2016 | Volume:23 | Issue:2 Page(s): 101-109

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Information Journal Paper

Title

COMPARISON OF ANTIOXIDANT PROPERTIES OF N- ACETYLCYSTEINE AND VITAMINS E AND C ON DIAZINON-INDUCED OXIDATIVE STRESS IN RAT SPLEEN

Author(s)

HEYDARI JAVAD | JAFARI MAHVASH | KHAZAIE SAEED | Issue Writer Certificate

Keywords

DIAZINONQ2

N-ACETYL CYSTEINEQ2

VITAMINS E AND CQ2

OXIDATIVE STRESSQ2

RAT SPLEENQ2

Abstract

Background and Aim: Organophosphate insecticides such as DIAZINON (DZN) can disrupt the body's antioxidant defense system. Antioxidants protect cells against OXIDATIVE STRESS. In the present study, antioxidant properties of N-acetylcysteine (NAC) and VITAMINS E AND C in reducing OXIDATIVE STRESS caused by DZN in RAT SPLEEN were compared.Materials and Methods: In this experimental study, 48 male Wistar rats were randomly divided into eight equal groups including. Control, DZN (100 mg/kg), NAC (160 mg/kg), vitamin E (150 mg/kg), vitamin C (200 mg/kg), NAC+DZN, vitamin E+DZN, and vitamin C+DZN groups. Twenty-four hours after intraperitoneal injection the animals were anesthetized and their spleen tissues were quickly removed. After tissues’ hemogenation superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), lactate dehydrogenase activities, as well as glutathione (GSH) and malondialdehyde levels were determined using biochemical methods.Results: DZN increased SOD and GST activities, but it decreased CAT activity and GSH content in the spleen. Administration of the antioxidant NAC or vitamin E caused SOD and GAT improvement.Conclusion: DZN induces OXIDATIVE STRESS in the spleen. NAC, through increasing the synthesis of GSH, vitamins E, and C- by removing free radicals- reduce DZN-induced OXIDATIVE STRESS. Comparing the effects of these antioxidants on GSH and GST activity indicates that the antioxidant value of NAC is greater than VITAMINS E AND C.

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APA: Copy

HEYDARI, JAVAD, JAFARI, MAHVASH, & KHAZAIE, SAEED. (2016). COMPARISON OF ANTIOXIDANT PROPERTIES OF N- ACETYLCYSTEINE AND VITAMINS E AND C ON DIAZINON-INDUCED OXIDATIVE STRESS IN RAT SPLEEN. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 23(2), 101-109. SID. https://sid.ir/paper/95516/en

Vancouver: Copy

HEYDARI JAVAD, JAFARI MAHVASH, KHAZAIE SAEED. COMPARISON OF ANTIOXIDANT PROPERTIES OF N- ACETYLCYSTEINE AND VITAMINS E AND C ON DIAZINON-INDUCED OXIDATIVE STRESS IN RAT SPLEEN. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;23(2):101-109. Available from: https://sid.ir/paper/95516/en

IEEE: Copy

JAVAD HEYDARI, MAHVASH JAFARI, and SAEED KHAZAIE, “COMPARISON OF ANTIOXIDANT PROPERTIES OF N- ACETYLCYSTEINE AND VITAMINS E AND C ON DIAZINON-INDUCED OXIDATIVE STRESS IN RAT SPLEEN,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 2, pp. 101–109, 2016, [Online]. Available: https://sid.ir/paper/95516/en

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