PROTECTIVE ROLE OF GREEN TEA (CAMELLIA SINENSIS) HYDROALCHOLIC EXTRACT ON SPERM PARAMETERS AND TESTICULAR TISSUE IN NMRI MICE EXPOSED TO SODIUM ARSENITE

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SHARIATZADEH SEYED MOHAMMAD ALI; MOHAMMADI MARYAM

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Journal: Journal of Birjand University of Medical Sciences Year:2015 | Volume:21 | Issue:4 Page(s): 432-443

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Title

PROTECTIVE ROLE OF GREEN TEA (CAMELLIA SINENSIS) HYDROALCHOLIC EXTRACT ON SPERM PARAMETERS AND TESTICULAR TISSUE IN NMRI MICE EXPOSED TO SODIUM ARSENITE

Author(s)

SHARIATZADEH SEYED MOHAMMAD ALI | MOHAMMADI MARYAM | Issue Writer Certificate

Keywords

SODIUM ARSENITEQ2

SPERM PARAMETERSQ2

GREEN TEA EXTRACTQ2

TESTISQ2

MICEQ2

Abstract

Background and Aim: SODIUM ARSENITE is an environmental pollutant with the capacity of generating free radicals and tissue damage. The aim of the current study was to investigate the effect of GREEN TEA EXTRACT (GTE), as an antioxidant, on SPERM PARAMETERS and TESTIS tissues of the MICE treated with SODIUM ARSENITE.Materials and Methods: Twenty-four adult male NMRI MICE with mean body weight 30±5g were randomly divided into 4 equal groups: control, SODIUM ARSENITE (5mg/kg/d.), GTE (100mg/kg/d.) and SODIUM ARSENITE+GTE. Oral treatments were performed as long as 34 days. At the end of treatments, body and left TESTIS weight were recorded and the left caudal epididymis of each subject was cut under Ham's F10. Then, the released spermatozoa were used to analyze SPERM PARAMETERS. Sperm chromatin quality was assessed by nuclear staining using acridine orange and aniline blue. The left TESTIS of each mouse was used for histopathological observation. The serum malondialdehyde (MDA) level was measured as an index of lipid peroxidation. Finally, the obtained data was analyzed by means of one-was ANOVA at the significant level P<0.05.Results: A significant decrease in the number, motility, viability (P<0.001) and normal morphology of sperm (P<0.01) and also in mean diameter of seminiferous tubules, germinal epithelium thickness (P<0.001) were found in the MICE treated with SODIUM ARSENITE compared to the controls. The MICE treated with SODIUM ARSENITE revealed a significant increase in the mean diameter of seminiferous tubules lumen and MDA levels (P<0.001). The above parameters were significantly compensated in the SODIUM ARSENITE+GTE group. SODIUM ARSENITE had no effect on the body and TESTIS weight, diameter of spermatogonial nucleus, sperm DNA integrity, and histone-protamine replacement.Conclusion: The results indicate that GREEN TEA EXTRACT can partially be useful in reducing SODIUM ARSENITE-induced toxicity.

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APA: Copy

SHARIATZADEH, SEYED MOHAMMAD ALI, & MOHAMMADI, MARYAM. (2015). PROTECTIVE ROLE OF GREEN TEA (CAMELLIA SINENSIS) HYDROALCHOLIC EXTRACT ON SPERM PARAMETERS AND TESTICULAR TISSUE IN NMRI MICE EXPOSED TO SODIUM ARSENITE. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 21(4), 432-443. SID. https://sid.ir/paper/95669/en

Vancouver: Copy

SHARIATZADEH SEYED MOHAMMAD ALI, MOHAMMADI MARYAM. PROTECTIVE ROLE OF GREEN TEA (CAMELLIA SINENSIS) HYDROALCHOLIC EXTRACT ON SPERM PARAMETERS AND TESTICULAR TISSUE IN NMRI MICE EXPOSED TO SODIUM ARSENITE. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;21(4):432-443. Available from: https://sid.ir/paper/95669/en

IEEE: Copy

SEYED MOHAMMAD ALI SHARIATZADEH, and MARYAM MOHAMMADI, “PROTECTIVE ROLE OF GREEN TEA (CAMELLIA SINENSIS) HYDROALCHOLIC EXTRACT ON SPERM PARAMETERS AND TESTICULAR TISSUE IN NMRI MICE EXPOSED TO SODIUM ARSENITE,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 4, pp. 432–443, 2015, [Online]. Available: https://sid.ir/paper/95669/en

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