ROLE OF BRAIN SEROTONERGIC AND NORADRENERGIC SYSTEMS ON BEHAVIORAL AND NEUROENDOCRINAL INDICES IN THE ANIMAL MODEL OF STRESS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

VAHABZADEH A.; KHAMENEH SAEID; MALEK A.; SALIMIKHALEGH H.; EBRAHIMI H.; DADASHZADEH S.; ABASI E.; KHORASANI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Birjand University of Medical Sciences Year:2001 | Volume:8 | Issue:1 (13) Page(s): 1-5

Download Full-Text

Persian Verion

View:

1,635

Download:

Cites:

Information Journal Paper

Title

ROLE OF BRAIN SEROTONERGIC AND NORADRENERGIC SYSTEMS ON BEHAVIORAL AND NEUROENDOCRINAL INDICES IN THE ANIMAL MODEL OF STRESS

Author(s)

Keywords

MICRODIALYSISQ4

SEROTONIN (5-HT)Q2

NORADEMALINEQ4

TAIL PINCHQ4

Abstract

Introduction and aim: In our previous studies using MICRODIALYSIS in the freely moving rats we showed the relation of stress with changes of noradrenaline (NA) and 5-Hydroxytryptamine(5-HT) release and synthesis in the rat brain. The present investigation aimed to study the role of brain 5-HT and NA systems on stress-induced behavioral responses.Material and Methods: Male Albino-Westar rats (200-300 g) were implanted with MICRODIALYSIS probes in the raphe, and lateral ventricle under chloral hydrate (500 mg/kg i. p.) anesthesia. Twelve hours after implantation animals were perfused at 2 ml/min with ringer solution. 5 min tali pinch is applied for control group. In the sham group ringer solution were perfused via MICRODIALYSIS probes while the TAIL PINCH (5 min) stress is performed. In one experiment, for the test group either Cd++ replaced with Ca++ in ringer solution or K+ (100 µM) added to the ringer solution. In another set of experiment, for the test group either clonidine (10 µM) or noradrenalin (20 µM) added to the ringer solution. The TAIL PINCH-induced behavioral responses were observed in all experimental groups. For validation of TAIL PINCH as a stressor, blood level of cortisone in control and TAIL PINCH groups were monitored. TAIL PINCH stress causes a variety of behavioral responses including gnawing, licking and aggression in rats. In the present study duration of these responses were observed at 5 min. Each group was compared. With the control animals. The statistical analysis was carried out using absolute data and either student paired t- test (within same group) or analysis of variance (ANOVA) statistical test (within the different groups).Results: The 5 minutes TAIL PINCH stress cause 231±11% increase in cortisol level. Local perfusion with potassium decrease the TAIL PINCH response to 37±6% of the sham group, while replacing calcium with cadmium in dorsal raphe nuclei increase TAIL PINCH response 110±2% of sham group. Local perfusion of conidian in lateral ventricle increase TAIL PINCH response to 112±3% of sham group.Conclusion: Data from the present study suggest an inhibitory role for 5-HT in those areas of the brain which may play a role in the stress-induced behaviors. Whereas in the other set of experiment just we found a contrary role for brain NA in the stress-induced behaviors.

Cites

No record.

References

No record.

Cite

APA: Copy

VAHABZADEH, A., KHAMENEH, SAEID, MALEK, A., SALIMIKHALEGH, H., EBRAHIMI, H., DADASHZADEH, S., ABASI, E., & KHORASANI, M.. (2001). ROLE OF BRAIN SEROTONERGIC AND NORADRENERGIC SYSTEMS ON BEHAVIORAL AND NEUROENDOCRINAL INDICES IN THE ANIMAL MODEL OF STRESS. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 8(1 (13)), 1-5. SID. https://sid.ir/paper/95759/en

Vancouver: Copy

VAHABZADEH A., KHAMENEH SAEID, MALEK A., SALIMIKHALEGH H., EBRAHIMI H., DADASHZADEH S., ABASI E., KHORASANI M.. ROLE OF BRAIN SEROTONERGIC AND NORADRENERGIC SYSTEMS ON BEHAVIORAL AND NEUROENDOCRINAL INDICES IN THE ANIMAL MODEL OF STRESS. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2001;8(1 (13)):1-5. Available from: https://sid.ir/paper/95759/en

IEEE: Copy

A. VAHABZADEH, SAEID KHAMENEH, A. MALEK, H. SALIMIKHALEGH, H. EBRAHIMI, S. DADASHZADEH, E. ABASI, and M. KHORASANI, “ROLE OF BRAIN SEROTONERGIC AND NORADRENERGIC SYSTEMS ON BEHAVIORAL AND NEUROENDOCRINAL INDICES IN THE ANIMAL MODEL OF STRESS,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 8, no. 1 (13), pp. 1–5, 2001, [Online]. Available: https://sid.ir/paper/95759/en

Related Journal Papers