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Information Journal Paper

Title

EFFECT OF LEVOTHYROXINE THERAPY ON THYROID PEROXIDASE ANTIBODY LEVEL IN 20-50 YEAR OLD FEMALES WITH HASHIMOTO’S DISEASE

Pages

  36-41

Keywords

ANTI-THYROID PEROXIDASE (ANTI-TPO)Q3

Abstract

 Background and Aim: HASHIMOTO's THYROIDITIS is the most prevalent cause of HYPOTHYROIDISM in children and adults. The disease clinically manifests itself in three forms; namely HYPOTHYROIDISM, EUTHYROIDISM, and hyperthyroidism. The present study was carried out aiming at determining anti-thyroid peroxidase antibody variation before and after levothyroxine treatment in HASHIMOTO's THYROIDITIS patients.Materials and Methods: In this quasi-experimental study, at first patients with firm goiter referring to Birjand glands deficiency clinic between 2005 and 2006 were examined and those with positive anti- TPO antibody were accounted as HASHIMOTO cases. Then, these cases were prescribed a three- month treatment with 100 microgram daily of levothyroxine. At the end of the period, their level of anti- TPO antibody was measured and their clinical conditions were assessed. The obtained data was then analysed by means of SPSS software; statistical tests including independent t, paired t test and chi-square test.Results: Majority (67.1%) of the patients was diagnosed as hypothyroid, and 32.9% were euthyroid cases. The level of anti-TPO antibody in 20% of the patients reached normal level after a period of three month treatment with levothyroxine. Mean anti-TPO antibody level before levothyroxine treatment was 450.74±122.05 IU/mL, which reduced to 236.2±153.96 IU/mL after treatment (P<0.001). Mean anti-TPO antibody level before treatment was higher (P<0.001) in hypothyroid patients compared with euthyroid ones. After treatment with levothyroxine, antibody level in hypothyroid cases also remained higher than that of euthyroid ones (P<0.001).Conclusion: Anti-TPO antibody level in HASHIMOTO patients with HYPOTHYROIDISM is higher than euthyroid ones. After treatment, anti-TPO antibody level decreases in both groups but the decrease is more prominent in euthyroid cases than patients who remain hypothyroid. Regarding these facts, it could be confirmed that anti-TPO antibody measurement (as an important diagnostic and follow-up procedure and for prognosis in HASHIMOTO) will be useful.

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    Cite

    APA: Copy

    KALBASI, S., HOSSEINI, HADI, NADI MOGHADAM, S., & SOLTANI, MANSOUR. (2007). EFFECT OF LEVOTHYROXINE THERAPY ON THYROID PEROXIDASE ANTIBODY LEVEL IN 20-50 YEAR OLD FEMALES WITH HASHIMOTO’S DISEASE. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 14(3 (32)), 36-41. SID. https://sid.ir/paper/95776/en

    Vancouver: Copy

    KALBASI S., HOSSEINI HADI, NADI MOGHADAM S., SOLTANI MANSOUR. EFFECT OF LEVOTHYROXINE THERAPY ON THYROID PEROXIDASE ANTIBODY LEVEL IN 20-50 YEAR OLD FEMALES WITH HASHIMOTO’S DISEASE. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2007;14(3 (32)):36-41. Available from: https://sid.ir/paper/95776/en

    IEEE: Copy

    S. KALBASI, HADI HOSSEINI, S. NADI MOGHADAM, and MANSOUR SOLTANI, “EFFECT OF LEVOTHYROXINE THERAPY ON THYROID PEROXIDASE ANTIBODY LEVEL IN 20-50 YEAR OLD FEMALES WITH HASHIMOTO’S DISEASE,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 14, no. 3 (32), pp. 36–41, 2007, [Online]. Available: https://sid.ir/paper/95776/en

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