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Information Journal Paper

Title

A meta-analysis for association between DGAT1 and Leptin genes polymorphisms with some milk production traits in dairy cows

Pages

  17-36

Keywords

Diacylglycerol O-Acyltransferase 1 (DGAT1) 

Abstract

 Background and objectives: The Polymorphisms in the major genes of Diacylglycerol OAcyltransferase 1 (DGAT1) and Leptin have drawn much attention from animal scientists during recent years, for their possible roles in the economically important traits. However, the association between these genes and milk production traits has been reported incompatible (sometimes significant and some other times without significant association) in Dairy cattle. The purpose of the present study was to investigate the association between DGAT1 and Leptin genes and some economically important traits including milk yield, milk fat and protein content and percentages in dairy cows by using meta-analysis. Materials and methods: All researches published in the theses and peer-reviewed journals up to 2018 were used. Following quality control, 9 and 4 studies reported for the Polymorphisms of K232A in DGAT1 and Sau3AI of Leptin gene were used, respectively. The analysis of the current study was carried out using the Stata v. 15. The Non-conformance index (I2) was significant for all parameters so that a random risk model was used. The effect size, 95% confidence interval, and statistical significance level of the measurements were calculated for each variable using this model. All variables were continuously in the current study. The measurement of the effect size for continuous data was carried out using the standardized mean difference (SMD) that was calculated for the Polymorphisms of K232A and Sau3AI loci in DGAT1 and Leptin genes on the milk yield, milk fat and protein content and percentage. Results: The results of the present research showed that the Polymorphism in the K223A locus of DGAT1 gene, has a significant effect on milk fat content and percentage, and can play an important role in their amounts, but its relationship with milk yield and protein content and percentage is not significant. Also, the results for Sau3AI Polymorphism in the Leptin revealed that this locus had no significant effect on the traits investigated in this study. Conclusion: The results of the present study with identifying the overall effects of the studied genotypes of DGAT1 and Leptin genes on milk production traits in dairy cows can play an important role in planning the use of the Polymorphisms of these genes in future researches.

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  • Cite

    APA: Copy

    GHORBANI, M., MORADI, M.H., Khaltabadi Farahani, A.H., & MIRZAEI, M.. (2021). A meta-analysis for association between DGAT1 and Leptin genes polymorphisms with some milk production traits in dairy cows. JOURNAL OF RUMINANT RESEARCH, 9(1 ), 17-36. SID. https://sid.ir/paper/958205/en

    Vancouver: Copy

    GHORBANI M., MORADI M.H., Khaltabadi Farahani A.H., MIRZAEI M.. A meta-analysis for association between DGAT1 and Leptin genes polymorphisms with some milk production traits in dairy cows. JOURNAL OF RUMINANT RESEARCH[Internet]. 2021;9(1 ):17-36. Available from: https://sid.ir/paper/958205/en

    IEEE: Copy

    M. GHORBANI, M.H. MORADI, A.H. Khaltabadi Farahani, and M. MIRZAEI, “A meta-analysis for association between DGAT1 and Leptin genes polymorphisms with some milk production traits in dairy cows,” JOURNAL OF RUMINANT RESEARCH, vol. 9, no. 1 , pp. 17–36, 2021, [Online]. Available: https://sid.ir/paper/958205/en

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