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Information Journal Paper

Title

The effect of high-intensity interval training (HIIT) on gene expression of the factors involved in the skeletal muscle metabolism of diabetic rats

Pages

  32-39

Abstract

 Introduction: Improving the metabolism of skeletal muscle is one of the important mechanisms for the treatment of type 2 Diabetes. The aim of this study was to evaluate the effect of High-Intensity Interval Training (HIIT) on gene expression of the factors involved in the skeletal muscle metabolism of diabetic Rats. Material and Methods: To implementation of this experimental research, 48 male Wistar Rats weighing 220 ± 20 gr randomly were divided into 4 groups including control, Diabetes, training and Diabetes-training. In this study, the Rats become Diabetes type 2 using peritoneal injection nicotinamide-STZ. High-Intensity Interval Training performed with intensity of 80-85% VO2max, 5 days a week and for 8 weeks. The expression of GLUT4 and PGC-1α genes were measured by Real Time PCR. Data were analyzed by One-way ANOVA and Tukey post hoc test at the P<0. 05. Results: The results showed a significant difference between the mean expression of GLUT4 and PGC-1α of skeletal muscle in diabetic Rats in different groups (P< 0. 001). The changes in the expression of GLUT4 and PGC-1α of the skeletal muscle in the Diabetes group were significantly lower than the control group (P=0. 036). High-Intensity Interval Training significantly caused higher the expression of GLUT4 and PGC-1α (P< 0. 001). Conclusion: According to the findings of the present study, High-Intensity Interval Training can help to improve cellular energy levels during Diabetes as a result of increasing the expression of PGC-1α and GLUT4 in skeletal muscle.

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    APA: Copy

    Bostan anesh, Mona, Shadmehri, Saeedeh, & Ahmadi, Mozhgan. (2019). The effect of high-intensity interval training (HIIT) on gene expression of the factors involved in the skeletal muscle metabolism of diabetic rats. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 17(2 ), 32-39. SID. https://sid.ir/paper/959733/en

    Vancouver: Copy

    Bostan anesh Mona, Shadmehri Saeedeh, Ahmadi Mozhgan. The effect of high-intensity interval training (HIIT) on gene expression of the factors involved in the skeletal muscle metabolism of diabetic rats. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2019;17(2 ):32-39. Available from: https://sid.ir/paper/959733/en

    IEEE: Copy

    Mona Bostan anesh, Saeedeh Shadmehri, and Mozhgan Ahmadi, “The effect of high-intensity interval training (HIIT) on gene expression of the factors involved in the skeletal muscle metabolism of diabetic rats,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 17, no. 2 , pp. 32–39, 2019, [Online]. Available: https://sid.ir/paper/959733/en

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