The Effects of Folic Acid on Testicular Histology, Sperm Quality, and Spermatogenesis Indices Following 3, 4-Methylenedioxymethamphetamine Exposure in Adult Male Rats

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Rad Iman; SABERI AREZOO; Koochakzadeh Nematollahi Najmeh Sadat; HABIBZADEH VICTORIA; Salarkia Ehsan; Amanollahi Sedigheh; Nikpour Saeideh

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Journal: Addiction and Health Year:2021 | Volume:13 | Issue:1 Page(s): 36-44

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Title

The Effects of Folic Acid on Testicular Histology, Sperm Quality, and Spermatogenesis Indices Following 3, 4-Methylenedioxymethamphetamine Exposure in Adult Male Rats

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Keywords

Folic acid

N-Methyl-3

4-methylenedioxyamphetamine

Spermatozoa

Spermatogenesis

Rats

Abstract

Background: There is an increasing concern over acute exposure of amphetamine and its derivative such as 3, 4-methylenedioxymethamphetamine (MDMA) on male reproductive toxicity. Supplementary vitamins can reduce the oxidative stresses and repair the damages on reproductive organs. This experimental study was conducted to evaluate the effects of Folic acid (FA) on reproductive indices, the antioxidant enzyme activities, and histological changes of testis on adult male Rats treated by MDMA. Methods: This experimental study was conducted on adult male Wistar Rats. Animals were divided into 4 groups: control, MDMA, FA, and MDMA + FA. Animals received a dose of 10 mg/kg of MDMA and 1 mg/kg of FA for 7 or 14 days. Rats were anesthetized and sperm quality parameters (number, concentration, motility, and morphology), Spermatogenesis indices [the mean seminiferous tubule diameter (MSTD), spermiogenesis index (SI), repopulation index (RI), and tubular differentiation index (TDI)], changes on testicular structure, antioxidant enzyme activities of catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA) beside serum level of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone were measured. Data were analyzed, using the one-way analysis of variance (ANOVA) and SPSS software. Findings: MDMA (both 7 and 14 days) caused significant changes in sperm quality (P < 0. 001), Spermatogenesis indices (P < 0. 001), testicular histopathology, and level of LH, FSH, testosterone beside the antioxidant enzyme activities (SOD, CAT, and MDA) (P < 0. 001). Supplementation of FA in association with MDMA partially reversed these parameters and made them close to the control group. Conclusion: The results suggested that FA could reduce the adverse effect of MDMA on reproductive ability in adult male Rats.

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APA: Copy

Rad, Iman, SABERI, AREZOO, Koochakzadeh Nematollahi, Najmeh Sadat, HABIBZADEH, VICTORIA, Salarkia, Ehsan, Amanollahi, Sedigheh, & Nikpour, Saeideh. (2021). The Effects of Folic Acid on Testicular Histology, Sperm Quality, and Spermatogenesis Indices Following 3, 4-Methylenedioxymethamphetamine Exposure in Adult Male Rats. ADDICTION AND HEALTH, 13(1 ), 36-44. SID. https://sid.ir/paper/960111/en

Vancouver: Copy

Rad Iman, SABERI AREZOO, Koochakzadeh Nematollahi Najmeh Sadat, HABIBZADEH VICTORIA, Salarkia Ehsan, Amanollahi Sedigheh, Nikpour Saeideh. The Effects of Folic Acid on Testicular Histology, Sperm Quality, and Spermatogenesis Indices Following 3, 4-Methylenedioxymethamphetamine Exposure in Adult Male Rats. ADDICTION AND HEALTH[Internet]. 2021;13(1 ):36-44. Available from: https://sid.ir/paper/960111/en

IEEE: Copy

Iman Rad, AREZOO SABERI, Najmeh Sadat Koochakzadeh Nematollahi, VICTORIA HABIBZADEH, Ehsan Salarkia, Sedigheh Amanollahi, and Saeideh Nikpour, “The Effects of Folic Acid on Testicular Histology, Sperm Quality, and Spermatogenesis Indices Following 3, 4-Methylenedioxymethamphetamine Exposure in Adult Male Rats,” ADDICTION AND HEALTH, vol. 13, no. 1 , pp. 36–44, 2021, [Online]. Available: https://sid.ir/paper/960111/en

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