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Title

The effect of progressive endurance training on heart resistance induced by infusion ischemia in healthy male rats

Pages

  67-77

Abstract

 Background and Objective: Myocardial infarction is one of the main causes of mortality in the world and Endurance exercise is one of the ways to prevent it. The present study aimed to investigate the effect of progressive endurance training on Heart resistance induced by infusion Ischemia in healthy male rats. Materials and Methods: 32 two-month-old male Wistar rats were used. Rats after one week of adaptation to the new conditions were randomly divided into four treatment groups with eight mice each: 1) health control group, 2) unhealthy control group, 3) health training group, and 4) unhealthy training group. The health training and unhealthy training groups were subjected to endurance training for eight weeks. To induce Ischemia, each mouse received Isoproterenol (85 mg/kg) intraperitoneally for two consecutive days. At the end of the experimental period, after anesthesia and isolation of rat and washing with ice-cold saline, then homogenization of Heart tissue was performed. The activities of superoxide dismutase, glutathione peroxidase, catalase, and myeloperoxidase enzymes were measured using specific kits and supernatants to evaluate the level of antioxidant activity. ELISA method were used and data analyzed with ANOVA test at the significant level of p<0. 05. Results: Cardiac Ischemia significantly reduced the activity of antioxidant enzymes and increased lipid peroxidation compared to the control (p=0. 001) and exercise groups (p=0. 002). Also, eight weeks of endurance training without Ischemia increased the activity of antioxidant enzymes (p=0. 002) and decreased myeloperoxidase compared to the Ischemia group (p=0. 001). Conclusion: Increasing endurance training by reducing Oxidative stress can have significant therapeutic effects against Isoproterenol-induced Oxidative stress damage and possibly reduce the complications of ischemic Heart failure.

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    APA: Copy

    OJAGHI, ALI, GHAZALIAN, FARSHAD, Vahdatpour, Tohid, Abednatanzi, Hossein, & BADALZADEH, REZA. (2021). The effect of progressive endurance training on heart resistance induced by infusion ischemia in healthy male rats. DANESHVAR MEDICINE, 29(153 ), 67-77. SID. https://sid.ir/paper/961045/en

    Vancouver: Copy

    OJAGHI ALI, GHAZALIAN FARSHAD, Vahdatpour Tohid, Abednatanzi Hossein, BADALZADEH REZA. The effect of progressive endurance training on heart resistance induced by infusion ischemia in healthy male rats. DANESHVAR MEDICINE[Internet]. 2021;29(153 ):67-77. Available from: https://sid.ir/paper/961045/en

    IEEE: Copy

    ALI OJAGHI, FARSHAD GHAZALIAN, Tohid Vahdatpour, Hossein Abednatanzi, and REZA BADALZADEH, “The effect of progressive endurance training on heart resistance induced by infusion ischemia in healthy male rats,” DANESHVAR MEDICINE, vol. 29, no. 153 , pp. 67–77, 2021, [Online]. Available: https://sid.ir/paper/961045/en

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