LIPOCALIN 2 EXPRESSION IN SCIATIC NERVE REGENERATION

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AGHANASIR FATEMEH; AGHAI HASSAN; NOURANI MOHAMMAD REZA

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Journal Paper

Paper Information

Journal: Annals of Military and Health Sciences Research Year:2012 | Volume:10 | Issue:3 (SERIAL NUMBER 39) Page(s): 198-206

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Title

LIPOCALIN 2 EXPRESSION IN SCIATIC NERVE REGENERATION

Author(s)

AGHANASIR FATEMEH | AGHAI HASSAN | NOURANI MOHAMMAD REZA | Issue Writer Certificate

Keywords

CRUSH INJURYQ2

OXIDATIVE STRESSQ2

ANTIOXIDANTSQ2

NGALQ2

Abstract

Background: Trauma is one of the causes of peripheral nerve injuries. Free radicals increase after tissue damages. Usually free radicals are scavenged and detoxified by ANTIOXIDANTS. In this study we assessed antioxidative role of NGAL (Neutrophil gelatinase associated lipocalin=Lipocalin2) molecule on crushed sciatic nerves of rats.Materials and Methods: In this study 40 rat's sciatic nerves were crushed and then at day 1 and 3 and week 1, 3, 5 after injury the sciatic nerve of rats which suffering crushed were extracted. First of all total mRNA of samples was extracted and then cDNA was synthesized. The expression of NGAL gene was confirmed by using semiquantitative RT-PCR analysis. For immunohistochemistry analysis, the samples were fixed in praformaldehyde and cut in 20 micrometer slices by cryostat.Results: The results showed that the expression of lipocalin 2 was significantly higher in day 1, day 3 and week 1 in crushed sciatic nerves in compare with the intact (non-injured) nerves (p<0.0001). Immunohistochemistry results also confirmed the protein expression of these genes.Conclusion: The sciatic nerve injuries cause OXIDATIVE STRESS which followed by CRUSH INJURY. In this research NGAL molecule showed maximum up-regulation in degeneration process after injury when OXIDATIVE STRESS have maximum peak. In this project for the first time we demonstrated the role of this molecule in degeneration and regeneration process of peripheral nerves and with more studies it may suggest as new complemental treatment.

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APA: Copy

AGHANASIR, FATEMEH, AGHAI, HASSAN, & NOURANI, MOHAMMAD REZA. (2012). LIPOCALIN 2 EXPRESSION IN SCIATIC NERVE REGENERATION. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, 10(3 (SERIAL NUMBER 39)), 198-206. SID. https://sid.ir/paper/96652/en

Vancouver: Copy

AGHANASIR FATEMEH, AGHAI HASSAN, NOURANI MOHAMMAD REZA. LIPOCALIN 2 EXPRESSION IN SCIATIC NERVE REGENERATION. ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH[Internet]. 2012;10(3 (SERIAL NUMBER 39)):198-206. Available from: https://sid.ir/paper/96652/en

IEEE: Copy

FATEMEH AGHANASIR, HASSAN AGHAI, and MOHAMMAD REZA NOURANI, “LIPOCALIN 2 EXPRESSION IN SCIATIC NERVE REGENERATION,” ANNALS OF MILITARY AND HEALTH SCIENCES RESEARCH, vol. 10, no. 3 (SERIAL NUMBER 39), pp. 198–206, 2012, [Online]. Available: https://sid.ir/paper/96652/en

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