Ferroptosis in Cardiovascular Disease: Basic Mechanisms and Implications for Cardiovascular Disease

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Farzipour Soghra; TALEBPOUR AMIRI FERESHTEH; Alvandi Maryam; Shaghaghi Zahra; YAZDI AMIRHOSSEIN

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2021 | Volume:31 | Issue:200 Page(s): 199-214

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Title

Ferroptosis in Cardiovascular Disease: Basic Mechanisms and Implications for Cardiovascular Disease

Author(s)

Keywords

ferroptosis

cardiovascular disease

ferroptosis inhibitors

Abstract

Ferroptosis is a new type of programmed cell death that plays an important role in various cardiovascular diseases, such as myocardial infarction, reperfusion injury, and heart failure. Cardiomyocyte loss is the most important determinant of morbidity and mortality, so, it is crucial to fully understand the regulatory mechanisms of ferroptosis signaling. In fact, inhibition of cardiac ferroptosis is a promising therapeutic strategy for cardiovascular diseases. However, the biological and pathological contexts in which ferroptosis might operate are poorly defined. Herein we discuss the role of ferroptosis in various cardiovascular diseases, provide an update on current knowledge about the molecular mechanisms that govern ferroptosis, and discuss about the role of ferroptosis inhibitors in control of ferroptosis induced cardiovascular disease in animal models.

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APA: Copy

Farzipour, Soghra, TALEBPOUR AMIRI, FERESHTEH, Alvandi, Maryam, Shaghaghi, Zahra, & YAZDI, AMIRHOSSEIN. (2021). Ferroptosis in Cardiovascular Disease: Basic Mechanisms and Implications for Cardiovascular Disease. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 31(200 ), 199-214. SID. https://sid.ir/paper/966764/en

Vancouver: Copy

Farzipour Soghra, TALEBPOUR AMIRI FERESHTEH, Alvandi Maryam, Shaghaghi Zahra, YAZDI AMIRHOSSEIN. Ferroptosis in Cardiovascular Disease: Basic Mechanisms and Implications for Cardiovascular Disease. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;31(200 ):199-214. Available from: https://sid.ir/paper/966764/en

IEEE: Copy

Soghra Farzipour, FERESHTEH TALEBPOUR AMIRI, Maryam Alvandi, Zahra Shaghaghi, and AMIRHOSSEIN YAZDI, “Ferroptosis in Cardiovascular Disease: Basic Mechanisms and Implications for Cardiovascular Disease,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 31, no. 200 , pp. 199–214, 2021, [Online]. Available: https://sid.ir/paper/966764/en

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