EVALUATION OF TEMPERATURE RISE AND THERMAL LESION DIMENSIONS IN LIVER LASER INTERSTITIAL THERMOTHERAPY

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GORJIARA T.; MOKHTARI DIZAJI M.; GHAANATI H.

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Journal: Iranian Journal of Medical Physics Year:2005 | Volume:2 | Issue:7 Page(s): 55-66

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Information Journal Paper

Title

EVALUATION OF TEMPERATURE RISE AND THERMAL LESION DIMENSIONS IN LIVER LASER INTERSTITIAL THERMOTHERAPY

Author(s)

GORJIARA T. | MOKHTARI DIZAJI M. | GHAANATI H. | Issue Writer Certificate

Keywords

LASER INTERSTITIAL THERMOTHERAPYQ4

LIVERQ2

TEMPERATURE MONITORINGQ3

THERMAL LESION DIMENSIONSQ4

POWER DENSITYQ4

Abstract

Introduction: LASER INTERSTITIAL THERMOTHERAPY (UTT) is an internal ablation therapy method consisting of a percutaneous or intraoperative insertion of laser fibers directly into the LIVER tumor with maximum diameter of 5 cm. In this treatment method, there isn't any general information about the relationship between increasing the exposure power, coagulation and carbonization areas with the changes in temperature. In this' study, according to the power range of UTI the changes in the temperature of LIVER tissue and the diameter of the necrotic area were measured.Materials and Methods: In vitro UTT was performed on fleshly sheep LIVER tissue using a bare-tip optical fiber from a Nd: Yag laser. A power setting of 2, 2.4, 3, 3.4, and 4 watt were used for an exposure time of 300 sec. The TEMPERATURE MONITORING was performed during the heating and cooling down by fixing micro thermocouples at 2.5 mm from the fiber tip. The thermal lesions which include necrosis and carbonization areas were compared for each power.Results: The result of the TEMPERATURE MONITORING was expressed as the mean value for each power. The temperature charts show that at 2.5 mm from the fiber tip the max tissue temperature is increased from 276.20°C (for a power setting of 2 watt and a 308 sec of exposure time) to 728.2°C (for a power setting of 3.4 watt and a 365 sec exposure time). At 6 mm from the fiber tip the max. temperature was measured to be 86.4°C for a power setting of 4 watt and 325 sec exposure time. For each power a non linear regression analysis was performed during the heating and cooling down for the dependent (temperature) and independent (time) parameters. The max. value for the cubic equation is shown to be R = 0.99 during the heating and for the exponential equation to be R=0.89 during the cooling down. A p value of 0.01 is considered significant. The diameter of the necrotic LIVER tissue increases from 12.95 mm at 600 joules to 16.15 mm at 1200 joules of energy. When the total applied energy is increased from 600 to 1200 joules, the thermal ablation increased by 25% while there was a 56% increase in the carbonization area. Increasing the carbonization area caused a decreases in the penetrability of the laser beam. Discussion and Conclusion: A useful treatment planning based on a non-linear regression analysis could be prepared for the treatment of hepatocellular carcinoma. In this analysis, the temperature changes in the necrotic area are monitored as a function of power setting in the range of 2-4 watts in UTT.

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APA: Copy

GORJIARA, T., MOKHTARI DIZAJI, M., & GHAANATI, H.. (2005). EVALUATION OF TEMPERATURE RISE AND THERMAL LESION DIMENSIONS IN LIVER LASER INTERSTITIAL THERMOTHERAPY. IRANIAN JOURNAL OF MEDICAL PHYSICS, 2(7), 55-66. SID. https://sid.ir/paper/96895/en

Vancouver: Copy

GORJIARA T., MOKHTARI DIZAJI M., GHAANATI H.. EVALUATION OF TEMPERATURE RISE AND THERMAL LESION DIMENSIONS IN LIVER LASER INTERSTITIAL THERMOTHERAPY. IRANIAN JOURNAL OF MEDICAL PHYSICS[Internet]. 2005;2(7):55-66. Available from: https://sid.ir/paper/96895/en

IEEE: Copy

T. GORJIARA, M. MOKHTARI DIZAJI, and H. GHAANATI, “EVALUATION OF TEMPERATURE RISE AND THERMAL LESION DIMENSIONS IN LIVER LASER INTERSTITIAL THERMOTHERAPY,” IRANIAN JOURNAL OF MEDICAL PHYSICS, vol. 2, no. 7, pp. 55–66, 2005, [Online]. Available: https://sid.ir/paper/96895/en

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