مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Monoclonal Antibody Against Sortilin Induces Apoptosis in Human Breast Cancer Cells

Pages

  37-45

Abstract

 Background: Sortilin has an important role in various malignances and can be used as a promising target to eradicate cancer cells. Methods: In this study, the expression of Sortilin in 4T1 and MDA-MB231 cell lines was evaluated by Flow cytometry and immunocytochemistry. Apoptosis assay was also applied to evaluate apoptosis induction in 4T1 and MDA-MB231 cell lines. Results: Based on cell surface Flow cytometry results, anti-Sortilin (2D8-E3) mAb could recognize Sortilin molecules in 79. 2% and 90. 3% of 4T1 and MDA-MB231 cell-lines, respectively. The immunocytochemistry staining results confirmed Sortilin surface expression. Apoptosis assay indicated that anti-Sortilin mAb could induce apoptosis in 4T1 and MDA-MB231 cell lines. Conclusion: Our study revealed the important role of surface Sortilin in breast carcinoma cell survival and its possible application as a therapeutic agent in cancer targeted therapies.

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    APA: Copy

    SIMONIAN, MIGANOOSH, Haji Ghaffari, Mozhan, SALIMI, ALI, MIRZADEGAN, EBRAHIM, Sadeghi, Niloufar, Ebrahimnezhad, Nasim, Fazli, Ghazaleh, FATEMI, RAMINA, BAYAT, ALI AHMAD, MILANI, SAEIDEH, NEGAHDARI, BABAK, & RABBANI, HODJATTALLAH. (2022). Monoclonal Antibody Against Sortilin Induces Apoptosis in Human Breast Cancer Cells. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), 14(1), 37-45. SID. https://sid.ir/paper/971618/en

    Vancouver: Copy

    SIMONIAN MIGANOOSH, Haji Ghaffari Mozhan, SALIMI ALI, MIRZADEGAN EBRAHIM, Sadeghi Niloufar, Ebrahimnezhad Nasim, Fazli Ghazaleh, FATEMI RAMINA, BAYAT ALI AHMAD, MILANI SAEIDEH, NEGAHDARI BABAK, RABBANI HODJATTALLAH. Monoclonal Antibody Against Sortilin Induces Apoptosis in Human Breast Cancer Cells. AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB)[Internet]. 2022;14(1):37-45. Available from: https://sid.ir/paper/971618/en

    IEEE: Copy

    MIGANOOSH SIMONIAN, Mozhan Haji Ghaffari, ALI SALIMI, EBRAHIM MIRZADEGAN, Niloufar Sadeghi, Nasim Ebrahimnezhad, Ghazaleh Fazli, RAMINA FATEMI, ALI AHMAD BAYAT, SAEIDEH MILANI, BABAK NEGAHDARI, and HODJATTALLAH RABBANI, “Monoclonal Antibody Against Sortilin Induces Apoptosis in Human Breast Cancer Cells,” AVICENNA JOURNAL OF MEDICAL BIOTECHNOLOGY (AJMB), vol. 14, no. 1, pp. 37–45, 2022, [Online]. Available: https://sid.ir/paper/971618/en

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