A SURVEY ON DRUG RESISTANCE IN GASTROINTESTINAL NEMATODES OF SHEEP USING LARVAL DEVELOPMENT ASSAY

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GHOLAMIAN A.; ESLAMI ALI; NABAVI L.; RASEKH A.A.R.; GALEHDARI H.

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Journal: SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL Year:2008 | Volume:4 | Issue:3 (20) Page(s): 48-57

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Title

A SURVEY ON DRUG RESISTANCE IN GASTROINTESTINAL NEMATODES OF SHEEP USING LARVAL DEVELOPMENT ASSAY

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Keywords

DRUG RESISTANCEQ2

GASTROINTESTINALQ3

NEMATODSQ2

SHEEPQ3

LARVAL DEVELOPMENT ASSAYQ3

Abstract

In this survey, resistance In GASTROINTESTINAL nematodes of SHEEP to levamisole and albendazole were investigated in 15 SHEEP flocks. On each flock, faecal samples were taken from 20 randomly selected SHEEP. Nematode eggs were separated from the samples and placed in microplate for 24 hours at 25c to hatch and then nutritive media, Escherichia coli and different concentrations of levamisole or albendazole were added to first stage larvae and incubated at 25°c for 6 more days. LD50 of these drugs in each flock were calculated according to precentage of larval development parameter in different concentration of levamisole or albendazole (0.008 to 8 mg/ml). To control the effects of other factors, none of the drugs was added to the first row of wells.Results of this survey showed that LD50 of levamisole were varied between 0.021 to 0.27mg/ml and LD50 of albendazole between 0.018 to 0.13mg/ml. In negative control samples with no anthelmintic. average larval development was 65% and third stage larvae were mostly composed of Ostertagia (59%). Trichostrongylus (20%) and Haemonchus (21%) but in positive control samples with the highest concentration of the drugs, only Ostertagia spp was detected. Therefore, we can conclude that efficacy of levamisole and albendazole in some of the flocks, were significantly reduced and development of resistant isolates of Ostertagia is the cause of this reduction.

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APA: Copy

GHOLAMIAN, A., ESLAMI, ALI, NABAVI, L., RASEKH, A.A.R., & GALEHDARI, H.. (2008). A SURVEY ON DRUG RESISTANCE IN GASTROINTESTINAL NEMATODES OF SHEEP USING LARVAL DEVELOPMENT ASSAY. SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL, 4(3 (20)), 48-57. SID. https://sid.ir/paper/97335/en

Vancouver: Copy

GHOLAMIAN A., ESLAMI ALI, NABAVI L., RASEKH A.A.R., GALEHDARI H.. A SURVEY ON DRUG RESISTANCE IN GASTROINTESTINAL NEMATODES OF SHEEP USING LARVAL DEVELOPMENT ASSAY. SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL[Internet]. 2008;4(3 (20)):48-57. Available from: https://sid.ir/paper/97335/en

IEEE: Copy

A. GHOLAMIAN, ALI ESLAMI, L. NABAVI, A.A.R. RASEKH, and H. GALEHDARI, “A SURVEY ON DRUG RESISTANCE IN GASTROINTESTINAL NEMATODES OF SHEEP USING LARVAL DEVELOPMENT ASSAY,” SCIENTIFIC-RESEARCH IRANIAN VETERINARY JOURNAL, vol. 4, no. 3 (20), pp. 48–57, 2008, [Online]. Available: https://sid.ir/paper/97335/en

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