Prognostic Accuracy of Cardiovascular Disease Biomarkers in Patients with COVID-19: A Diagnostic Test Accuracy Meta-analysis

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NASIR KANSESTANI ATEFEH; ZARE MOHAMMAD ERFAN; ZHANG JUN

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Paper Information

Journal: THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER Year:2021 | Volume:16 | Issue:1 Page(s): 1-14

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Title

Prognostic Accuracy of Cardiovascular Disease Biomarkers in Patients with COVID-19: A Diagnostic Test Accuracy Meta-analysis

Author(s)

NASIR KANSESTANI ATEFEH | ZARE MOHAMMAD ERFAN | ZHANG JUN | Issue Writer Certificate

Keywords

COVID-19

Biomarkers

Lactate dehydrogenase

Troponin I

Prognosis

Abstract

Background: Several reports have determined that cardiovascular diseases (CVDs) are common complications in patients with coronavirus disease 2019 (COVID-19) and lead them to poor outcomes. CVD Biomarkers have, thus, great potential to be used as prognostic Biomarkers. We aimed to determine the accuracy of CVD Biomarkers for the Prognosis of the COVID-19 patient’ s outcome via a diagnostic test accuracy (DTA) meta-analysis. Methods: Until September 30, 2020, we searched Web of Sciences, Scopus, and MEDLINE/PubMed databases to obtain related papers. The summary points and lines were calculated using bivariate/HSROC model. As outcomes, we considered critical conditions and mortality. Results: A total of 17 659 patients from 33 studies were included. Five Biomarkers, namely increased levels of Lactate dehydrogenase (LDH), cardiac Troponin I (cTnI), creatine kinase (CK), D-dimer, and thrombocytopenia, met the inclusion criteria. Our results indicated that LDH and cTnI had good accuracy for the Prognosis of critical condition (AUCHSROC=0. 83 and 0. 80, respectively), while LDH, cTnI, and D-dimer had acceptable accuracy (AUCHSROC=0. 74, 0. 71, and 0. 72, respectively) for the Prognosis of mortality. LDH and D-dimer had high sensitivity, whereas cTnI had high specificity. The other Biomarkers did not have acceptable accuracy. Significant publication bias was found for D-dimer (P=0. 053). Conclusion: Among CVD Biomarkers, LDH and cTnI had good accuracy for the Prognosis of critical outcomes and acceptable accuracy for the Prognosis of mortality, without publication bias. Given their different sensitivities and specificities, we recommend the use of these 2 Biomarkers concomitantly.

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APA: Copy

NASIR KANSESTANI, ATEFEH, ZARE, MOHAMMAD ERFAN, & ZHANG, JUN. (2021). Prognostic Accuracy of Cardiovascular Disease Biomarkers in Patients with COVID-19: A Diagnostic Test Accuracy Meta-analysis. THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER, 16(1), 1-14. SID. https://sid.ir/paper/973741/en

Vancouver: Copy

NASIR KANSESTANI ATEFEH, ZARE MOHAMMAD ERFAN, ZHANG JUN. Prognostic Accuracy of Cardiovascular Disease Biomarkers in Patients with COVID-19: A Diagnostic Test Accuracy Meta-analysis. THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER[Internet]. 2021;16(1):1-14. Available from: https://sid.ir/paper/973741/en

IEEE: Copy

ATEFEH NASIR KANSESTANI, MOHAMMAD ERFAN ZARE, and JUN ZHANG, “Prognostic Accuracy of Cardiovascular Disease Biomarkers in Patients with COVID-19: A Diagnostic Test Accuracy Meta-analysis,” THE JOURNAL OF TEHRAN UNIVERSITY HEART CENTER, vol. 16, no. 1, pp. 1–14, 2021, [Online]. Available: https://sid.ir/paper/973741/en

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