SYNTHESIS OF THE DL-[3H] LEUCINE

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MATLOUBI H.A.; SHIRVANI GH.H.; SAEMIAN N.

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ISSN: 2588-4824

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Journal: JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY Year:2005 | Volume:- | Issue:1 (33) Page(s): 9-14

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Title

SYNTHESIS OF THE DL-[3H] LEUCINE

Author(s)

MATLOUBI H.A. | SHIRVANI GH.H. | SAEMIAN N. | Issue Writer Certificate

Keywords

TRITIUMQ4

LEUCINEQ4

TALASEMIQ4

AMINO ACIDSQ4

Abstract

Labelled organic compounds have been widely applied to solve the research problems in life, science and chemistry. The preparation of labelled compounds with carbon-14 and TRITIUM-3 are probably more extensively and variously used in compare with any other isotopes. These isotopes emit only beta-particle. In this paper the synthesis of DL [3H] LEUCINE which was prepared for the first time in Iran is described. This compound is used for diagnosis of TALASEMI disease. The synthetic pathwayis achieved by using the condensation of methyl allyl chloride with diethyl acetamido malonate in the presence of sodium ethoxid in ethanol .In the next step of the synthesis. the latter compound was hydrogenated with 3H2(g.) over the Adams catalyst in chloroform. which was produced ethyl 2- acetamido-2- carbetoxy -4-methyl pentanoate with a yield of 100%. In final step, the resulted product was converted directly to [4.5-3H] LEUCINE with the specific activity 5 Ci/mmol. by reflaxing with the hydrobromic acid of 48%.

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APA: Copy

MATLOUBI, H.A., SHIRVANI, GH.H., & SAEMIAN, N.. (2005). SYNTHESIS OF THE DL-[³H] LEUCINE. JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY, -(1 (33)), 9-14. SID. https://sid.ir/paper/97627/en

Vancouver: Copy

MATLOUBI H.A., SHIRVANI GH.H., SAEMIAN N.. SYNTHESIS OF THE DL-[³H] LEUCINE. JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY[Internet]. 2005;-(1 (33)):9-14. Available from: https://sid.ir/paper/97627/en

IEEE: Copy

H.A. MATLOUBI, GH.H. SHIRVANI, and N. SAEMIAN, “SYNTHESIS OF THE DL-[³H] LEUCINE,” JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY, vol. -, no. 1 (33), pp. 9–14, 2005, [Online]. Available: https://sid.ir/paper/97627/en

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