STUDY OF STRAND BREAKS INDUCED BY DIRECT EFFECTS OF MONOENERGETIC ELECTRONS IN B CONFORMATION OF GENETIC MATERIAL OF LIVING CELLS BY USING GEANT4

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SEMSARHA F.; RAISALI G.R.; GOLIAEI B.; KHALAFI H.

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Journal: JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY Year:2015 | Volume:- | Issue:71 Page(s): 51-59

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Title

STUDY OF STRAND BREAKS INDUCED BY DIRECT EFFECTS OF MONOENERGETIC ELECTRONS IN B CONFORMATION OF GENETIC MATERIAL OF LIVING CELLS BY USING GEANT4

Author(s)

SEMSARHA F. | RAISALI G.R. | GOLIAEI B. | KHALAFI H. | Issue Writer Certificate

Keywords

MONOENERGETIC ELECTRONSQ1

SINGLE STRAND BREAKQ2

DOUBLE STRAND BREAKQ1

VOLUME MODEL OF B-DNAQ2

GEANT4Q2

Abstract

In this study, DNA damage and statistics of hit in any compartments of B-DNA conformation of genetic material of living cells, induced by MONOENERGETIC ELECTRONS, have been studied using Monte Carlo GEANT4 (Geometry and tracking 4)-DNA toolkit. Simple 34 bp segments of B-DNA conformation, repeated randomly in high number, and MONOENERGETIC ELECTRONS (1-20 keV) have been simulated in a volume of typical animal cell nucleus. The average yields of single strand and double strand damage for this energy range of electrons were 24.6 Gy-1Gbp-1 and 0.295 Gy-1Gbp-1, respectively. The highest hit efficiency is for phosphodiester volume of B-DNA model and the most SINGLE STRAND BREAK damage yield has been calculated for 8 keV electrons. The averaged DSB to SSB fraction for this energy range electrons is about 0.031.

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APA: Copy

SEMSARHA, F., RAISALI, G.R., GOLIAEI, B., & KHALAFI, H.. (2015). STUDY OF STRAND BREAKS INDUCED BY DIRECT EFFECTS OF MONOENERGETIC ELECTRONS IN B CONFORMATION OF GENETIC MATERIAL OF LIVING CELLS BY USING GEANT4. JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY, -(71), 51-59. SID. https://sid.ir/paper/97672/en

Vancouver: Copy

SEMSARHA F., RAISALI G.R., GOLIAEI B., KHALAFI H.. STUDY OF STRAND BREAKS INDUCED BY DIRECT EFFECTS OF MONOENERGETIC ELECTRONS IN B CONFORMATION OF GENETIC MATERIAL OF LIVING CELLS BY USING GEANT4. JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY[Internet]. 2015;-(71):51-59. Available from: https://sid.ir/paper/97672/en

IEEE: Copy

F. SEMSARHA, G.R. RAISALI, B. GOLIAEI, and H. KHALAFI, “STUDY OF STRAND BREAKS INDUCED BY DIRECT EFFECTS OF MONOENERGETIC ELECTRONS IN B CONFORMATION OF GENETIC MATERIAL OF LIVING CELLS BY USING GEANT4,” JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY, vol. -, no. 71, pp. 51–59, 2015, [Online]. Available: https://sid.ir/paper/97672/en

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