Preparation and Biological Evaluation of [111In]-THPP [5, 10, 15, 20-tetrakis (4-Hydroxyphenyl) Porphyrin] Complex in Healthy Rats Via SPECT Imaging

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SADEGHI S.; JALILIAN A.R.; MIRZAII M.; MORADKHANI S.

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Journal: JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY Year:2016 | Volume:- | Issue:77 Page(s): 62-69

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Title

Preparation and Biological Evaluation of [111In]-THPP [5, 10, 15, 20-tetrakis (4-Hydroxyphenyl) Porphyrin] Complex in Healthy Rats Via SPECT Imaging

Author(s)

SADEGHI S. | JALILIAN A.R. | MIRZAII M. | MORADKHANI S. | Issue Writer Certificate

Keywords

Hydroxyphenyl PorphyrinQ1

IndiumQ1

BiodistributionQ2

SPECTQ1

Abstract

The aim of this research was the synthesis of 111In-THPP, and its evaluation as a new imaging agent. The 111In-THPP radiotracer was synthesized by 111InCl3 and 5, 10, 15, 20-tetrakis (4-hydroxyphenyl) porphyrin) (THPP) in solution for 60 min at 80˚ C. In-111 radionuclide was produced from proton bombardment of natCd target using 30MeV protons and 150μ A current. Separation was achieved using ion chromatography method with the separation yield of >98%. In order to determine the radiolabeling yield (or metallation) radio thin layer chromatography (RTLC) and high performance liquid chromatography (HPLC) were used (with the radiochemical yield of >99% for both methods). The radiolabeled compound was injected to the healthy rats and the Biodistribution studies were performed using scarification. The single photon emission computed tomography (SPECT) imaging within 2-24h shows the accumulation of 111In-THPP in the kidneys, compared to other organs. 111In-THPP is essentially excreted via kidneys. Due to relatively low liver uptake and kidney wash-out, 111In-THPP could be a potential agent for imaging.

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APA: Copy

SADEGHI, S., JALILIAN, A.R., MIRZAII, M., & MORADKHANI, S.. (2016). Preparation and Biological Evaluation of [111In]-THPP [5, 10, 15, 20-tetrakis (4-Hydroxyphenyl) Porphyrin] Complex in Healthy Rats Via SPECT Imaging. JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY, -(77 ), 62-69. SID. https://sid.ir/paper/97817/en

Vancouver: Copy

SADEGHI S., JALILIAN A.R., MIRZAII M., MORADKHANI S.. Preparation and Biological Evaluation of [111In]-THPP [5, 10, 15, 20-tetrakis (4-Hydroxyphenyl) Porphyrin] Complex in Healthy Rats Via SPECT Imaging. JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY[Internet]. 2016;-(77 ):62-69. Available from: https://sid.ir/paper/97817/en

IEEE: Copy

S. SADEGHI, A.R. JALILIAN, M. MIRZAII, and S. MORADKHANI, “Preparation and Biological Evaluation of [111In]-THPP [5, 10, 15, 20-tetrakis (4-Hydroxyphenyl) Porphyrin] Complex in Healthy Rats Via SPECT Imaging,” JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY, vol. -, no. 77 , pp. 62–69, 2016, [Online]. Available: https://sid.ir/paper/97817/en

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