Conolidine: A Novel Plant Extract for Chronic Pain

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Edinoﬀ Amber N.; Patel Akash S.; Baker Mitchell W.; Lawson Jesse; Wolcott Christopher; Cornett Elyse M.; SADEGI KAMBIZ; Kaye Adam M.; Kaye Alan D.

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Journal Paper

Paper Information

Journal: Anesthesiology and Pain Medicine Year:2021 | Volume:11 | Issue:6 Page(s): 0-0

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Title

Conolidine: A Novel Plant Extract for Chronic Pain

Author(s)

Keywords

Conolidine

Chronic Pain

Tabernaemontana divaricate

Atypical Chemokine Receptor

Endogenous Opiates

Abstract

Pain, the most common symptom reported among patients in the primary care setting, is complex to manage. Opioids are among the most potent analgesics agents for managing pain. Since the mid-1990s, the number of opioid prescriptions for the management of chronic non-cancer pain (CNCP) has increased by more than 400%, and this increased availability has signiﬁ cantly contributed to opioid diversion, overdose, tolerance, dependence, and addiction. Despite the questionable eﬀ ectiveness of opioids in managing CNCP and their high rates of side eﬀ ects, the absence of available alternative medications and their clinical limitations and slower onset of action has led to an overreliance on opioids. Conolidine is an indole alkaloid derived from the bark of the tropical ﬂ owering shrub Tabernaemontana divaricate used in traditional Chinese, Ayurvedic, and Thai medicine. Conolidine could represent the beginning of a new era of Chronic Pain management. It is now being investigated for its eﬀ ects on the Atypical Chemokine Receptor (ACK3). In a rat model, it was found that a competitor molecule binding to ACKR3 resulted in inhibition of ACKR3’ s inhibitory activity, causing an overall increase in opiate receptor activity. Although the identiﬁ cation of Conolidine as a potential novel analgesic agent provides an additional avenue to address the opioid crisis and manage CNCP, further studies are necessary to understand its mechanism of action and utility and eﬃ cacy in managing CNCP.

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APA: Copy

Edinoﬀ, Amber N., Patel, Akash S., Baker, Mitchell W., Lawson, Jesse, Wolcott, Christopher, Cornett, Elyse M., SADEGI, KAMBIZ, Kaye, Adam M., & Kaye, Alan D.. (2021). Conolidine: A Novel Plant Extract for Chronic Pain. ANESTHESIOLOGY AND PAIN MEDICINE, 11(6), 0-0. SID. https://sid.ir/paper/980492/en

Vancouver: Copy

Edinoﬀ Amber N., Patel Akash S., Baker Mitchell W., Lawson Jesse, Wolcott Christopher, Cornett Elyse M., SADEGI KAMBIZ, Kaye Adam M., Kaye Alan D.. Conolidine: A Novel Plant Extract for Chronic Pain. ANESTHESIOLOGY AND PAIN MEDICINE[Internet]. 2021;11(6):0-0. Available from: https://sid.ir/paper/980492/en

IEEE: Copy

Amber N. Edinoﬀ, Akash S. Patel, Mitchell W. Baker, Jesse Lawson, Christopher Wolcott, Elyse M. Cornett, KAMBIZ SADEGI, Adam M. Kaye, and Alan D. Kaye, “Conolidine: A Novel Plant Extract for Chronic Pain,” ANESTHESIOLOGY AND PAIN MEDICINE, vol. 11, no. 6, pp. 0–0, 2021, [Online]. Available: https://sid.ir/paper/980492/en

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