EFFECT OF ALLOXAN ON PANCREATIC BETA CELLS' APOPTOSIS IN RAT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

DOUSTAR Y.; GARJANI A.R.; HASHEMI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2006 | Volume:16 | Issue:1 Page(s): 29-33

Download Full-Text

Persian Verion

View:

1,904

Download:

Cites:

Information Journal Paper

Title

EFFECT OF ALLOXAN ON PANCREATIC BETA CELLS' APOPTOSIS IN RAT

Author(s)

DOUSTAR Y. | GARJANI A.R. | HASHEMI M. | Issue Writer Certificate

Keywords

ALLOXANQ2

APOPTOSISQ3

PANCREATIC BETA CELLQ3

Abstract

Background: ALLOXAN is a potent generative of reactive oxygen species (ROS), which can mediate B-cell toxicity. Reactive oxygen metabolites have been demonstrated to cause apoptotic cell death. The aim of this study was to investigate ALLOXAN-induced morphological alterations in APOPTOSIS. Materials and methods: For this experimental study, wistar rats weighed 200 g were chosen and assigned into four groups of five as follows. The treatment rats received ALLOXAN (45, 90 and 135mg/kg intraperitoneally) and control group rats received saline normal. 48 hours following the injection, pancreatic tissue samples were obtained. The selected tissue samples were fixed in 10% formalin solution and then microscopic sections with the thickness of 5-6 micron were prepared and stained with TUNEL method. Meanwhile, at 12-, 24-, 48- and 36-hour intervals blood samples were obtained from all rats to check blood sugar level. Results: Treatment groups showed apoptotic cells in PANCREATIC BETA CELLs and high blood sugar in biochemistry laboratory test in comparison with controls. Indeed, the mean number of apoptotic cells in five microscopic fields of all treated groups was significantly (p<0.001) higher than the control group. Conclusion: Mechanism of ALLOXAN-induced APOPTOSIS has not been fully understood; however, evidences indicate that the PANCREATIC BETA CELL damage is mediated through the generation of cytotoxic oxygen free radicals.

Cites

No record.

References

بررسی هیستوپاتولوژیکی ضایعات کبد و لوزالمعده در دیابت ملیتوس تجربی ایجاد شده بوسیله آلوکسان در بز

Cite

APA: Copy

DOUSTAR, Y., GARJANI, A.R., & HASHEMI, M.. (2006). EFFECT OF ALLOXAN ON PANCREATIC BETA CELLS' APOPTOSIS IN RAT. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 16(1), 29-33. SID. https://sid.ir/paper/98488/en

Vancouver: Copy

DOUSTAR Y., GARJANI A.R., HASHEMI M.. EFFECT OF ALLOXAN ON PANCREATIC BETA CELLS' APOPTOSIS IN RAT. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2006;16(1):29-33. Available from: https://sid.ir/paper/98488/en

IEEE: Copy

Y. DOUSTAR, A.R. GARJANI, and M. HASHEMI, “EFFECT OF ALLOXAN ON PANCREATIC BETA CELLS' APOPTOSIS IN RAT,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 16, no. 1, pp. 29–33, 2006, [Online]. Available: https://sid.ir/paper/98488/en

Related Journal Papers