ALTERATIONS OF GYRA IN ENTEROBACTERIACEAE ISOLATED OF URINARY TRACT ‎INFECTION RESISTANCE TO QUINOLONES ANTIBIOTICS

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MONAVARI ATOUSA; NOURBAKHSH FATEMEH; YALFANI ROOZBEH

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Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2017 | Volume:27 | Issue:2 Page(s): 133-137

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Title

ALTERATIONS OF GYRA IN ENTEROBACTERIACEAE ISOLATED OF URINARY TRACT ‎INFECTION RESISTANCE TO QUINOLONES ANTIBIOTICS

Author(s)

MONAVARI ATOUSA | NOURBAKHSH FATEMEH | YALFANI ROOZBEH | Issue Writer Certificate

Keywords

ANTIBIOTICS RESISTANCEQ2

QUINOLONEQ2

GYRA GENEQ1

ENTEROBACTERACAEQ2

PCRQ2

Abstract

Background: Urinary tract infection is one of the most common infections, which if not treated, it can ‎cause serious problems in patients. One of the ways to treat of this infection is antibiotic therapy. ‎Nowaday, antibiotic resistance in microorganisms is a main problem for physicians and patients in the ‎world. The aim of this study was to evaluate the genetic resistance to QUINOLONEs antibiotics in ‎Enterobacteriaceae isolated in urine samples.Materials and methods: 100 bacteria of Enterobacteriaceae family were isolated from suspected ‎samples of urinary infection. Antibiotic susceptibility of isolated bacteria to QUINOLONE antibiotics, ‎including ciprofloxacin, nalidixic acid, norfloxacin, ofloxacin, levofloxacin and enrofloaxin, was ‎performed by disc diffusion method according to standard guidelines (CLSI 2014). PCR was ‎performed by specific primers of GYRA GENE.‎Results: Hundred bacteria were isolated of clinical urine sample including 60 E.coli, 32 Klebsiella, 3 ‎Enterobacter, and 5 Proteus. Antibiotic resistance to ciprofloxacin were 36%, nalidixic acid 45%, ‎norfloxacin 38%, ofloxacin 38%, levofloxacin 35% and enrofloaxin 39%. Totally, 36 bacteria were ‎resist to all antibiotics, which 29 bacteria (80.55%) revealed mutation in GYRA GENE.Conclusion: This study revealed that Ecoli isolates carry a mutation in GYRA GENEs. This mutation has ‎an important role in antibiotic resistance to quinolons.‎ Keywords: ANTIBIOTICS RESISTANCE, QUINOLONE, GYRA GENE, ENTEROBACTERACAE, PCR.‎

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APA: Copy

MONAVARI, ATOUSA, NOURBAKHSH, FATEMEH, & YALFANI, ROOZBEH. (2017). ALTERATIONS OF GYRA IN ENTEROBACTERIACEAE ISOLATED OF URINARY TRACT ‎INFECTION RESISTANCE TO QUINOLONES ANTIBIOTICS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 27(2), 133-137. SID. https://sid.ir/paper/98580/en

Vancouver: Copy

MONAVARI ATOUSA, NOURBAKHSH FATEMEH, YALFANI ROOZBEH. ALTERATIONS OF GYRA IN ENTEROBACTERIACEAE ISOLATED OF URINARY TRACT ‎INFECTION RESISTANCE TO QUINOLONES ANTIBIOTICS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2017;27(2):133-137. Available from: https://sid.ir/paper/98580/en

IEEE: Copy

ATOUSA MONAVARI, FATEMEH NOURBAKHSH, and ROOZBEH YALFANI, “ALTERATIONS OF GYRA IN ENTEROBACTERIACEAE ISOLATED OF URINARY TRACT ‎INFECTION RESISTANCE TO QUINOLONES ANTIBIOTICS,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 27, no. 2, pp. 133–137, 2017, [Online]. Available: https://sid.ir/paper/98580/en

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