ASSOCIATION OF D19H POLYMORPHISM OF ABCG8 GENE WITH GALLSTONE SUSCEPTIBILITY

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MILANIZADEH SAMAN; MOHAMMAD ALIZADEH AMIR HOUSHANG; AZIMZADEH PEDRAM; ROMANI SARA; ROSHANI MOHAMMAD; KHAN YAGHMA MAHSA; MOHEBBI SEYED REZA; ZALI MOHAMMAD REZA

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2013 | Volume:23 | Issue:3 Page(s): 185-189

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Title

ASSOCIATION OF D19H POLYMORPHISM OF ABCG8 GENE WITH GALLSTONE SUSCEPTIBILITY

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Keywords

GALL STONEQ3

ABCG8Q1

POLYMORPHISMQ2

D19HQ2

Abstract

Background: Increased level of cholesterol may be saturated in the gall bladder resulting in GALL STONE. Product of ABCG8 gene is responsible for evacuation of cholesterol from cells and made dissolved cholesterol in bile. It appears that genetic changes of this gene can alter its function and make GALL STONE. This study was designed to evaluate association of D19H POLYMORPHISM of ABCG8 gene with gallstone susceptibility.Materials and Methods: This was a case-control research that was conducted on 100 gallstone patients and 106 healthy controls without any family history of gallstone. For DNA extraction, salting out method has been used and for detection of alleles in polymorphic region, PCR-RFLP has been used.Results: heterozygote genotype in this polymorphic region (G/C) had association with gallstone formation (OR=7.14; 95%CI=3.47-14.66; P<0.001). We found that people with heterozygote genotype had more than 7 times susceptibility to GALL STONE compared to healthy controls.Conclusion: This study confirms previous studies about D19H POLYMORPHISM on ABCG8 gene and shows importance of this SNP in different populations. For this reason, we can use analysis of this region to predict susceptibility to GALL STONE formation.

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APA: Copy

MILANIZADEH, SAMAN, MOHAMMAD ALIZADEH, AMIR HOUSHANG, AZIMZADEH, PEDRAM, ROMANI, SARA, ROSHANI, MOHAMMAD, KHAN YAGHMA, MAHSA, MOHEBBI, SEYED REZA, & ZALI, MOHAMMAD REZA. (2013). ASSOCIATION OF D19H POLYMORPHISM OF ABCG8 GENE WITH GALLSTONE SUSCEPTIBILITY. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 23(3), 185-189. SID. https://sid.ir/paper/98595/en

Vancouver: Copy

MILANIZADEH SAMAN, MOHAMMAD ALIZADEH AMIR HOUSHANG, AZIMZADEH PEDRAM, ROMANI SARA, ROSHANI MOHAMMAD, KHAN YAGHMA MAHSA, MOHEBBI SEYED REZA, ZALI MOHAMMAD REZA. ASSOCIATION OF D19H POLYMORPHISM OF ABCG8 GENE WITH GALLSTONE SUSCEPTIBILITY. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2013;23(3):185-189. Available from: https://sid.ir/paper/98595/en

IEEE: Copy

SAMAN MILANIZADEH, AMIR HOUSHANG MOHAMMAD ALIZADEH, PEDRAM AZIMZADEH, SARA ROMANI, MOHAMMAD ROSHANI, MAHSA KHAN YAGHMA, SEYED REZA MOHEBBI, and MOHAMMAD REZA ZALI, “ASSOCIATION OF D19H POLYMORPHISM OF ABCG8 GENE WITH GALLSTONE SUSCEPTIBILITY,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 23, no. 3, pp. 185–189, 2013, [Online]. Available: https://sid.ir/paper/98595/en

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