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Information Journal Paper

Title

ANTI BACTERIAL SCAFFOLDS BASED ON GUM TRAGACANTH FOR WOUND CARING UNDER MOIST CONDITIONS

Pages

  206-211

Abstract

 Background: When hydrocolloids dressings are loaded with an antibacterial agent, they can also prevent infection during wound cicatrisation. To consider interesting properties of traditional GUM TRAGACANTH such as moisture absorption, hydrocolloid formation, drug holding and releasing abilities, it was aimed to introduce a SCAFFOLD wound dress based on GUM TRAGACANTH with drug release ability simultaneously.Materials and Methods: In this experimental study, GUM TRAGACANTH from Astragalus gossypinus species (Iranian species) is solved and loaded with an aminoglycoside antibiotic (Gentamicin). Prepared solution transformed to a nano fibers network “scaffold” by LYOPHILIZATION method. Samples were characterized by scanning electron microscopy, fourier transform infrared and X-ray diffraction methods and their antimicrobial and moisture holding properties were determined.Results: GUM TRAGACANTH showed a proper potential for dispersing GENTAMICIN and the drug was loaded into polymer matrix without any aggregation. Loaded GUM TRAGACANTH with GENTAMICIN is successfully transformed to a nanofibers SCAFFOLD by LYOPHILIZATION. The diameters of fibers were in the range of 300nm to 2µm. Transformed GUM TRAGACANTH into SCAFFOLDs showed declined regain content (up to 50%) due to the ordering and orientation of polymer chains. Ordered hydroxyl groups also observed in FTIR graphs. Regarding the zones of inhibition, SCAFFOLDs also showed acceptable antibacterial activities.Conclusion: Produced SCAFFOLDs are capable of absorbing wound’s exocrine liquid easily due to their high specific area of nanofibers. When it is turned to gel by moisture sorption, the release of loaded GENTAMICIN would be enhanced.

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    APA: Copy

    KHAJAVI, RAMIN, HAJMALEKI, MARYAM, SHAHMIRZAEI ASHTIYANI, FARHAD, TOLIAT, TAYEBEH, SATTARI, MORTEZA, & MIRJALILI, MOHAMMAD. (2013). ANTI BACTERIAL SCAFFOLDS BASED ON GUM TRAGACANTH FOR WOUND CARING UNDER MOIST CONDITIONS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 23(3), 206-211. SID. https://sid.ir/paper/98600/en

    Vancouver: Copy

    KHAJAVI RAMIN, HAJMALEKI MARYAM, SHAHMIRZAEI ASHTIYANI FARHAD, TOLIAT TAYEBEH, SATTARI MORTEZA, MIRJALILI MOHAMMAD. ANTI BACTERIAL SCAFFOLDS BASED ON GUM TRAGACANTH FOR WOUND CARING UNDER MOIST CONDITIONS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2013;23(3):206-211. Available from: https://sid.ir/paper/98600/en

    IEEE: Copy

    RAMIN KHAJAVI, MARYAM HAJMALEKI, FARHAD SHAHMIRZAEI ASHTIYANI, TAYEBEH TOLIAT, MORTEZA SATTARI, and MOHAMMAD MIRJALILI, “ANTI BACTERIAL SCAFFOLDS BASED ON GUM TRAGACANTH FOR WOUND CARING UNDER MOIST CONDITIONS,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 23, no. 3, pp. 206–211, 2013, [Online]. Available: https://sid.ir/paper/98600/en

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