PROTECTIVE EFFECTS OF VITAMIN E ON SPERM CHARACTERISTICS AND SOME SERUM PARAMETERS IN MICE TOXICITY INDUCED BY DIANABOL

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BABAEI MOHAMMAD; TOOTIAN ZAHRA; MOROVATI HASAN; SHOJAEI BAHADOR; FAZELIPOUR SIMIN

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Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2018 | Volume:28 | Issue:2 Page(s): 81-91

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Title

PROTECTIVE EFFECTS OF VITAMIN E ON SPERM CHARACTERISTICS AND SOME SERUM PARAMETERS IN MICE TOXICITY INDUCED BY DIANABOL

Author(s)

Keywords

VITAMIN EQ2

DIANABOLQ1

SPERMQ2

TESTOSTERONEQ2

MICEQ2

Abstract

Background: Anabolic steroid drugs, especially DIANABOL, were used as energy producer drug for growth and enhancement of muscles in athletes. Using of anabolic-androgenic steroids among athletes is extended. However, there are limited information about the adverse effects of mentioned drugs on genital system. This study aimed to evaluation of protective effects of VITAMIN E against damages caused by DIANABOL on male genital system. Materials and methods: In this experimental study, 72 male MICE grouped randomly to one control group and seven experimental groups (n=9). MICE in experimental groups 1, 5, 6 and 7 received VITAMIN E with dose 100 IU/kgBW. Experimental groups 5, 6 and 7 were administrated DIANABOL with doses 5, 10 and 20 mg/kgBW after 4 hours of VITAMIN E reception. MICE in experimental groups 2, 3 and 4 received just DIANABOL with doses 5, 10 and 20 mg/kgBW. Administration method in all groups was orally by gavage for 42 days. 24 hours after last treatment, blood samples were collected from heart and SPERM characteristics were evaluated. Results: Results showed significant decrease in total antioxidant capacity (TAC) and increase in malondialdehyde (MDA) in serum; VITAMIN E administration remarkably improved above mentioned parameters. Also, VITAMIN E administration caused improvement in SPERM parameters and blood TESTOSTERONE level. Conclusion: This study showed that VITAMIN E, as inhibitor of free radical, can decrease oxidative damages caused by DIANABOL.

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APA: Copy

BABAEI, MOHAMMAD, TOOTIAN, ZAHRA, MOROVATI, HASAN, SHOJAEI, BAHADOR, & FAZELIPOUR, SIMIN. (2018). PROTECTIVE EFFECTS OF VITAMIN E ON SPERM CHARACTERISTICS AND SOME SERUM PARAMETERS IN MICE TOXICITY INDUCED BY DIANABOL. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 28(2 ), 81-91. SID. https://sid.ir/paper/98605/en

Vancouver: Copy

BABAEI MOHAMMAD, TOOTIAN ZAHRA, MOROVATI HASAN, SHOJAEI BAHADOR, FAZELIPOUR SIMIN. PROTECTIVE EFFECTS OF VITAMIN E ON SPERM CHARACTERISTICS AND SOME SERUM PARAMETERS IN MICE TOXICITY INDUCED BY DIANABOL. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2018;28(2 ):81-91. Available from: https://sid.ir/paper/98605/en

IEEE: Copy

MOHAMMAD BABAEI, ZAHRA TOOTIAN, HASAN MOROVATI, BAHADOR SHOJAEI, and SIMIN FAZELIPOUR, “PROTECTIVE EFFECTS OF VITAMIN E ON SPERM CHARACTERISTICS AND SOME SERUM PARAMETERS IN MICE TOXICITY INDUCED BY DIANABOL,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 28, no. 2 , pp. 81–91, 2018, [Online]. Available: https://sid.ir/paper/98605/en

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