EFFICIENCY IMPROVEMENT OF FLUTICASONE PROPIONATE DRY POWDER FORMULATION FOR INHALATION IN PULMONARY PATIENTS

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VATANPARAST ZAHRA; ASGHARIAN RAMIN; MORTAZAVI SEYED MORTEZA; GILANI KAMBIZ

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Paper Information

Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2016 | Volume:26 | Issue:2 Page(s): 89-94

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Title

EFFICIENCY IMPROVEMENT OF FLUTICASONE PROPIONATE DRY POWDER FORMULATION FOR INHALATION IN PULMONARY PATIENTS

Author(s)

VATANPARAST ZAHRA | ASGHARIAN RAMIN | MORTAZAVI SEYED MORTEZA | GILANI KAMBIZ | Issue Writer Certificate

Keywords

DRY POWDER INHALER (DPI)Q1

FLUTICASONE PROPIONATEQ2

LACTOSEQ2

MANNITOLQ3

Abstract

Background: Nowadays, inhaled corticosteroids have become the core of therapy for patients with asthma and chronic obstructive pulmonary disease (COPD). FLUTICASONE PROPIONATE (FP) is among the most lipophilic steroids (water solubility ~0.1 mg/ml) and its clinical efficacy has been confirmed in many studies. The inclusion of different carrier materials in a dry powder inhaler (DPI) system can alter formulation performance, which might be attributable to variation in the adhesion between drug and carrier particles.Materials and methods: To this aim, we used two different carriers to be mixed in different times with drug on the one hand to facilitate the powder flow during manufacturing, and on the other hand to help fluidization upon patient inhalation. The prepared DPI formulations were examined in terms of drug content uniformity upon the physical blending, particle shape, and in vitro pulmonary deposition. The latter was determined using an Andersen cascade impactor and Cyclohaler® as a single-dose DPI.Results: Our results revealed that the highest fine particle fraction (FPF) and fine particle dose (FPD) value belonged to the formulation contained FP: MANNITOL, mixed in 30 minutes.Conclusion: It can be concluded that using MANNITOL as the coarse carrier can improve the physical properties as well as the aerosolization behavior of the resultant DPI formulations.

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References

THE GENERATION OF RESPIRABLE CLOUDS FROM COARSE POWDER AGGREGATES

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APA: Copy

VATANPARAST, ZAHRA, ASGHARIAN, RAMIN, MORTAZAVI, SEYED MORTEZA, & GILANI, KAMBIZ. (2016). EFFICIENCY IMPROVEMENT OF FLUTICASONE PROPIONATE DRY POWDER FORMULATION FOR INHALATION IN PULMONARY PATIENTS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 26(2), 89-94. SID. https://sid.ir/paper/98662/en

Vancouver: Copy

VATANPARAST ZAHRA, ASGHARIAN RAMIN, MORTAZAVI SEYED MORTEZA, GILANI KAMBIZ. EFFICIENCY IMPROVEMENT OF FLUTICASONE PROPIONATE DRY POWDER FORMULATION FOR INHALATION IN PULMONARY PATIENTS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2016;26(2):89-94. Available from: https://sid.ir/paper/98662/en

IEEE: Copy

ZAHRA VATANPARAST, RAMIN ASGHARIAN, SEYED MORTEZA MORTAZAVI, and KAMBIZ GILANI, “EFFICIENCY IMPROVEMENT OF FLUTICASONE PROPIONATE DRY POWDER FORMULATION FOR INHALATION IN PULMONARY PATIENTS,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 26, no. 2, pp. 89–94, 2016, [Online]. Available: https://sid.ir/paper/98662/en

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