EFFECTS OF AQUEOUS EXTRACT OF ZINGIBER OFFICINALE ON LIPID PROFILES IN RAT SUBJECTED TO STREPTOZOTOCIN

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SHAHRIVAR TAHMOORES; MOKHTARI MOKHTAR; ALIPOUR VALI

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Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2018 | Volume:28 | Issue:3 Page(s): 230-238

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Title

EFFECTS OF AQUEOUS EXTRACT OF ZINGIBER OFFICINALE ON LIPID PROFILES IN RAT SUBJECTED TO STREPTOZOTOCIN

Author(s)

SHAHRIVAR TAHMOORES | MOKHTARI MOKHTAR | ALIPOUR VALI | Issue Writer Certificate

Keywords

ZINGIBERQ2

STREPTOZOTOCINQ2

LDLQ3

HDLQ3

TRIGLYCERIDESQ3

TOTAL CHOLESTEROLQ2

RATQ1

Abstract

Background: Diabetes induces systemic disorders through changes in plasma lipid levels and increasing risk of cardiovascular diseases. In this study, the effects of aqueous extract of ZINGIBER officinale on the serum levels of lipids was investigated in RATs following the induction of diabetes by STREPTOZOTOCIN. Materials and methods: In this experimental study, 42 male Wistar RATs were divided in 6 groups of seven as follow: the control, diabetic sham and 4 experimental groups. Diabetic sham received 70 mg/kg STREPTOZOTOCIN once at the beginning of the experiment; the experimental groups 1 and 2 daily received 250 and 500 mg/kg ZINGIBER aqueous extract respectively; the experimental groups 3 and 4 first received STREPTOZOTOCIN once, and then a daily dose of 250 and 500 mg/kg extract. Oral administration of aqueous extract continued over a period of two months. Then, blood samples were prepared, and used for measurement of serum levels of TRIGLYCERIDES (TG), TOTAL CHOLESTEROL (TC), LDL cholesterol and HDL cholesterol. Results: Serum concentration of triglyceride and LDL cholesterol in the diabetic sham compared to the control group showed a significant increase (p<0. 05). Conversely, serum levels of triglyceride and LDL cholesterol in the experimental group 1 compared to the control group indicated a significant decrease. Triglyceride in the experimental group 2 revealed a significant increase compared to the control group. Also, HDL cholesterol increased significantly in this group. A significant decrease was observed in the serum levels of triglyceride and LDL cholesterol in the experimental group3 and 4 compared with diabetic sham, whereas concentration of HDL cholesterol in experimental Group 4 increased significantly (p< 0. 05). Conclusion: Due to its antioxidant properties, aqueous extract of ZINGIBER can reduce STREPTOZOTOCIN toxicity leading to an improvement in serum lipid profiles of diabetic patients.

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APA: Copy

SHAHRIVAR, TAHMOORES, MOKHTARI, MOKHTAR, & ALIPOUR, VALI. (2018). EFFECTS OF AQUEOUS EXTRACT OF ZINGIBER OFFICINALE ON LIPID PROFILES IN RAT SUBJECTED TO STREPTOZOTOCIN. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 28(3 ), 230-238. SID. https://sid.ir/paper/98697/en

Vancouver: Copy

SHAHRIVAR TAHMOORES, MOKHTARI MOKHTAR, ALIPOUR VALI. EFFECTS OF AQUEOUS EXTRACT OF ZINGIBER OFFICINALE ON LIPID PROFILES IN RAT SUBJECTED TO STREPTOZOTOCIN. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2018;28(3 ):230-238. Available from: https://sid.ir/paper/98697/en

IEEE: Copy

TAHMOORES SHAHRIVAR, MOKHTAR MOKHTARI, and VALI ALIPOUR, “EFFECTS OF AQUEOUS EXTRACT OF ZINGIBER OFFICINALE ON LIPID PROFILES IN RAT SUBJECTED TO STREPTOZOTOCIN,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 28, no. 3 , pp. 230–238, 2018, [Online]. Available: https://sid.ir/paper/98697/en

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