EFFECTS OF CITRUS AURANTIUM EXTRACT ON ANTIOXIDANT ACTIVITY AND TESTOSTERONE LEVEL IN MALE MICE

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MINAEE MARZIEH; KHAKPOUR SHAHRZAD; KHOSRAVI MARYAM; ARBABIYAN SEDIGHE

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Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2012 | Volume:22 | Issue:2 Page(s): 101-104

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Title

EFFECTS OF CITRUS AURANTIUM EXTRACT ON ANTIOXIDANT ACTIVITY AND TESTOSTERONE LEVEL IN MALE MICE

Author(s)

MINAEE MARZIEH | KHAKPOUR SHAHRZAD | KHOSRAVI MARYAM | ARBABIYAN SEDIGHE | Issue Writer Certificate

Keywords

CITRUS AURANTIUM EXTRACTQ2

TESTOSTERONEQ2

ANTIOXIDANT ACTIVITYQ2

MICEQ2

Abstract

Background: CITRUS AURANTIUM EXTRACT (C. aurantium) is a native and high intake plant of Iran. The aim of this study was to investigate the effect of C. aurantium on ANTIOXIDANT ACTIVITY and TESTOSTERONE level of male healthy MICE.Materials and Methods: In this experimental study, Twenty- eight healthy adult male Balb/C MICE were divided into four groups; each group includes seven MICE. Two milliliter distilled water, C. aurantium extract with low concentration (0.01 mg/kg), C. aurantium extract with medium concentration (0.02 mg/kg), and C. aurantium extract with high concentration (0.04 mg/kg) were given daily for seven weeks by gavage to MICE in the first, second, third, and fourth groups, respectively. Level of TESTOSTERONE, lipid peroxidation and antioxidant enzyme activities were investigated. Data were analyzed by analysis of variance (ANOVA) and the degree of significance was set at p<0.05.Results: A significant decrease in malondialdehyde (MDA) level (p<0.01) and marked increases in glutathione (GSH) (p<0.01), glutathione peroxidase (GSH-Px) (p<0.05) and catalase (CAT) (p<0.01) activities were observed in MICE treated with different doses of C. aurantium. TESTOSTERONE level significantly decreased compared to the control group (p<0.01 and p<0.05).Conclusion: It seems there is a negative relation between C. aurantium consumption and TESTOSTERONE level.

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APA: Copy

MINAEE, MARZIEH, KHAKPOUR, SHAHRZAD, KHOSRAVI, MARYAM, & ARBABIYAN, SEDIGHE. (2012). EFFECTS OF CITRUS AURANTIUM EXTRACT ON ANTIOXIDANT ACTIVITY AND TESTOSTERONE LEVEL IN MALE MICE. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 22(2), 101-104. SID. https://sid.ir/paper/98719/en

Vancouver: Copy

MINAEE MARZIEH, KHAKPOUR SHAHRZAD, KHOSRAVI MARYAM, ARBABIYAN SEDIGHE. EFFECTS OF CITRUS AURANTIUM EXTRACT ON ANTIOXIDANT ACTIVITY AND TESTOSTERONE LEVEL IN MALE MICE. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2012;22(2):101-104. Available from: https://sid.ir/paper/98719/en

IEEE: Copy

MARZIEH MINAEE, SHAHRZAD KHAKPOUR, MARYAM KHOSRAVI, and SEDIGHE ARBABIYAN, “EFFECTS OF CITRUS AURANTIUM EXTRACT ON ANTIOXIDANT ACTIVITY AND TESTOSTERONE LEVEL IN MALE MICE,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 22, no. 2, pp. 101–104, 2012, [Online]. Available: https://sid.ir/paper/98719/en

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