STUDY OF CYTOTOXICITY EFFECT OF TOTAL SAFFRON EXTRACT ON HEPATOCARCINOMA CELL LINE (HEPG2)

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NEZHAD SHAHROKHABADI KH.; TAVAKOL AFSHARI J.; RAKHSHANDEH HASAN; BOROUK A.

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2009 | Volume:19 | Issue:3 (57) Page(s): 154-159

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Title

STUDY OF CYTOTOXICITY EFFECT OF TOTAL SAFFRON EXTRACT ON HEPATOCARCINOMA CELL LINE (HEPG2)

Author(s)

NEZHAD SHAHROKHABADI KH. | TAVAKOL AFSHARI J. | RAKHSHANDEH HASAN | BOROUK A. | Issue Writer Certificate

Keywords

SAFFRON EXTRACTQ2

MTT ASSAYQ3

L929 CELL LINEQ3

HEPATOCARCINOMAQ3

ANTI-TOMURQ3

Abstract

Background: The anti-tumor effect of SAFFRON EXTRACT has been proved in both in vitro and in vivo in recent years. In this study, cytotoxicity effect of total SAFFRON EXTRACT on human liver carsinoma cells (HepG2) investigated in in vitro condition.Materials and methods: In this experimental study, the effects of total SAFFRON EXTRACT on quantitative proliferation of all cell lines were determined by using 3-(4, 5-dimethyl thiazol-2yl) -2,5-diphenyl tetrazolium bromide (MTT) colorimetric assay. Also, effects of extract on mouse fibroblast cells (L929) were evaluated as the control. MTT ASSAY is a fast, sensitive and quantitative method for all kind of cell’s proliferation by spectrophotometry. Amount of required extract for occurring 50% cytotoxicity to the cells (IC 50) was achieved by administering different concentration of extract, and comparing the left alive cells with cells that no drug was used on them.Results: 50% inhibition of tumor cells growth was achieved at 400 mg/ml. Extract had no inhibitory effect on normal cells growth.Conclusion: Total SAFFRON EXTRACT can be used as cytotoxic agent against Cancer in vivo by producing cytoplasmic and nuclear changes.

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APA: Copy

NEZHAD SHAHROKHABADI, KH., TAVAKOL AFSHARI, J., RAKHSHANDEH, HASAN, & BOROUK, A.. (2009). STUDY OF CYTOTOXICITY EFFECT OF TOTAL SAFFRON EXTRACT ON HEPATOCARCINOMA CELL LINE (HEPG2). MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 19(3 (57)), 154-159. SID. https://sid.ir/paper/98811/en

Vancouver: Copy

NEZHAD SHAHROKHABADI KH., TAVAKOL AFSHARI J., RAKHSHANDEH HASAN, BOROUK A.. STUDY OF CYTOTOXICITY EFFECT OF TOTAL SAFFRON EXTRACT ON HEPATOCARCINOMA CELL LINE (HEPG2). MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2009;19(3 (57)):154-159. Available from: https://sid.ir/paper/98811/en

IEEE: Copy

KH. NEZHAD SHAHROKHABADI, J. TAVAKOL AFSHARI, HASAN RAKHSHANDEH, and A. BOROUK, “STUDY OF CYTOTOXICITY EFFECT OF TOTAL SAFFRON EXTRACT ON HEPATOCARCINOMA CELL LINE (HEPG2),” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 19, no. 3 (57), pp. 154–159, 2009, [Online]. Available: https://sid.ir/paper/98811/en

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