EFFECT OF SALVIA OFFICINALIS L. EXTRACT ON MALONDIALDEHYDE AGAINST STREPTOZOTOCIN-INDUCED OXIDATIVE STRESS IN RAT’S BRAIN

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SHAHMOHAMADI SHAHRAM; KHOSRAVI MARYAM; HAJIZADEH MOGHADDAM AKBAR

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2014 | Volume:23 | Issue:4 Page(s): 225-229

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Title

EFFECT OF SALVIA OFFICINALIS L. EXTRACT ON MALONDIALDEHYDE AGAINST STREPTOZOTOCIN-INDUCED OXIDATIVE STRESS IN RAT’S BRAIN

Author(s)

SHAHMOHAMADI SHAHRAM | KHOSRAVI MARYAM | HAJIZADEH MOGHADDAM AKBAR | Issue Writer Certificate

Keywords

OXIDATIVE STRESSQ2

SALVIA OFFICINALISQ2

STREPTOZOTOCINQ2

MALONDIALDEHYDEQ2

RATQ2

Abstract

Background: OXIDATIVE STRESS is caused by an imbalance between oxidative and the anti-oxidative systems in the living tissues. OXIDATIVE STRESS in brain causes brain dysfunction, destruction of neurons, and diseases like Alzheimer. In the present study, we examined the protective effect of SALVIA OFFICINALIS L. against STREPTOZOTOCIN-induced OXIDATIVE STRESS in RAT’s brain.Materials and Methods: In this experimental study, Wistar RATs were divided into control, Sham, and three experimental groups received 25, 50 and 100 mg/kg hydroalcoholic extract of SALVIA OFFICINALIS intraperitoneally, respectively. After two weeks, surgical procedure was performed on sham and experimental groups and after one week recovery, STREPTOZOTOCIN was injected intra-cerebroventricularly (ICV-STZ) at 3 mg/kg. Brain hemispheres were collected after fourth week. Finally, MALONDIALDEHYDE (MDA)) level was measured in brain hemispheres tissues.Results: STZ significantly increased MDA levels compared to the control group (P<0.001), whereas intraperitoneally injection of different doses of SALVIA OFFICINALIS leaves extract significantly decreased MDA levels (P<0.001).Conclusion: We concluded that antioxidant effect of SALVIA OFFICINALIS L. could prevent OXIDATIVE STRESS induced by ICV injection of STZ in the brain of male RAT.

Cites

PROTECTIVE EFFECTS OF VOLUNTARY EXERCISE AND EXTRACT OF SALVIA OFFICINALIS ON DIAZINON INDUCED HEPATOTOXICITY IN RATS

References

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APA: Copy

SHAHMOHAMADI, SHAHRAM, KHOSRAVI, MARYAM, & HAJIZADEH MOGHADDAM, AKBAR. (2014). EFFECT OF SALVIA OFFICINALIS L. EXTRACT ON MALONDIALDEHYDE AGAINST STREPTOZOTOCIN-INDUCED OXIDATIVE STRESS IN RAT’S BRAIN. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 23(4), 225-229. SID. https://sid.ir/paper/98824/en

Vancouver: Copy

SHAHMOHAMADI SHAHRAM, KHOSRAVI MARYAM, HAJIZADEH MOGHADDAM AKBAR. EFFECT OF SALVIA OFFICINALIS L. EXTRACT ON MALONDIALDEHYDE AGAINST STREPTOZOTOCIN-INDUCED OXIDATIVE STRESS IN RAT’S BRAIN. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2014;23(4):225-229. Available from: https://sid.ir/paper/98824/en

IEEE: Copy

SHAHRAM SHAHMOHAMADI, MARYAM KHOSRAVI, and AKBAR HAJIZADEH MOGHADDAM, “EFFECT OF SALVIA OFFICINALIS L. EXTRACT ON MALONDIALDEHYDE AGAINST STREPTOZOTOCIN-INDUCED OXIDATIVE STRESS IN RAT’S BRAIN,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 23, no. 4, pp. 225–229, 2014, [Online]. Available: https://sid.ir/paper/98824/en

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