FREQUENCY OF TNFα-244GÀA, TNFα-308GÀA AND TNFα-238GÀA POLYMORPHISMS IN HEALTHY AND MALARIA INFECTED PATIENTS OF KERMAN AND HORMOZGAN PROVINCES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

ATEF VAHID PARISA; ALIVAND MOHAMMAD REZA; HASHEMI GORJI FEYZOLLAH; HASHEMI MEHRDAD; NOORI DALOII MOHAMMAD REZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2011 | Volume:21 | Issue:1 (63) Page(s): 18-23

Download Full-Text

Persian Verion

View:

605

Download:

Cites:

Information Journal Paper

Title

FREQUENCY OF TNFα-244GÀA, TNFα-308GÀA AND TNFα-238GÀA POLYMORPHISMS IN HEALTHY AND MALARIA INFECTED PATIENTS OF KERMAN AND HORMOZGAN PROVINCES

Author(s)

Keywords

MALARIAQ3

POLYMORPHISMQ2

TNFαQ2

PCR-RFLPQ2

Abstract

Background: Tumor necrosis factor-alpha (TNFa) is one of the key cytokines that affects on pathology of microbial infections. It is suggested that genetic susceptibility to severe form of MALARIA is associated with TNFa promoter POLYMORPHISMs. The aim of present study was to investigate frequency of -308GàA, -244GàA and -238GàA POLYMORPHISM in 174 samples of Hormozgan and Kerman provinces.Material and methods: In case- control study, we investigated the prevalence of TNFa-244GàA, TNFa-308GàA and TNFa-238GàA POLYMORPHISM in 174 (154 healthy and 20 patients) individuals from Kerman and Hormozgan provinces of Iran. DNA extraction performed, and then PCR-RFLP was used to detect POLYMORPHISMs in -308,-244 and -238 loci.Results: In these three regions, 82.2% of healthy samples showed GG genotype, 14.26% AG and 0.19% AA. All samples of patients showed GG genotype in these three regions.Conclusion: It seems that evolutionary effect of MALARIA causes increased genotypes which related with protection against MALARIA or reduction of risk of cerebral MALARIA and death, although, there was no association between frequency of these genotypes and protection against MALARIA.

Cites

No record.

References

No record.

Cite

APA: Copy

ATEF VAHID, PARISA, ALIVAND, MOHAMMAD REZA, HASHEMI GORJI, FEYZOLLAH, HASHEMI, MEHRDAD, & NOORI DALOII, MOHAMMAD REZA. (2011). FREQUENCY OF TNFα-244GÀA, TNFα-308GÀA AND TNFα-238GÀA POLYMORPHISMS IN HEALTHY AND MALARIA INFECTED PATIENTS OF KERMAN AND HORMOZGAN PROVINCES. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 21(1 (63)), 18-23. SID. https://sid.ir/paper/98841/en

Vancouver: Copy

ATEF VAHID PARISA, ALIVAND MOHAMMAD REZA, HASHEMI GORJI FEYZOLLAH, HASHEMI MEHRDAD, NOORI DALOII MOHAMMAD REZA. FREQUENCY OF TNFα-244GÀA, TNFα-308GÀA AND TNFα-238GÀA POLYMORPHISMS IN HEALTHY AND MALARIA INFECTED PATIENTS OF KERMAN AND HORMOZGAN PROVINCES. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2011;21(1 (63)):18-23. Available from: https://sid.ir/paper/98841/en

IEEE: Copy

PARISA ATEF VAHID, MOHAMMAD REZA ALIVAND, FEYZOLLAH HASHEMI GORJI, MEHRDAD HASHEMI, and MOHAMMAD REZA NOORI DALOII, “FREQUENCY OF TNFα-244GÀA, TNFα-308GÀA AND TNFα-238GÀA POLYMORPHISMS IN HEALTHY AND MALARIA INFECTED PATIENTS OF KERMAN AND HORMOZGAN PROVINCES,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 21, no. 1 (63), pp. 18–23, 2011, [Online]. Available: https://sid.ir/paper/98841/en

Related Journal Papers