PROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF CROCUS SATIVUS L.(SAFFRON) STIGMA AGAINST CISPLATIN INDUCED HEPATOTOXICITY IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOHAJERI DARYOUSH; DOUSTAR YOUSEF

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2012 | Volume:21 | Issue:4 (66) Page(s): 251-261

Download Full-Text

Persian Verion

View:

1,383

Download:

Cites:

Information Journal Paper

Title

PROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF CROCUS SATIVUS L.(SAFFRON) STIGMA AGAINST CISPLATIN INDUCED HEPATOTOXICITY IN RATS

Author(s)

MOHAJERI DARYOUSH | DOUSTAR YOUSEF | Issue Writer Certificate

Keywords

CROCUS SATIVUS L.Q2

CISPLATINQ2

HEPATOTOXICITYQ2

ANTI-OXIDANTQ2

RATQ2

Abstract

Background: CISPLATIN, as an important anti-cancer drug, is a potent hepatotoxicant.The aim of the present study was to evaluate the protective effect of ethanolic extract of CROCUS SATIVUS L.stigma (EECSL.S) against CISPLATIN-induced HEPATOTOXICITY in the RATs.Materials and methods: 40 male Wistar RATs were randomly allocated into 5 groups (1-Normal control, 2- Toxicant control, 3-Positive control and 4&5- Treatment with extract) of 8 animals each.Cisplatin was injected (0.4 mg/kg) to groups 2-4 daily for 8 weeks, intraperitoneally.Simultaneously, normal saline (10 ml/kg) for groups 1 and 2, silymarin (50 mg/kg) for group 3 and EECSL.S (40 and 80 mg/kg) for groups 4 and 5 were administered through the gavage.At the end of experiment, levels of serum biomarkers of hepatic injury as well as antioxidant activity in liver homogenates of the RATs were assessed.Moreover, histopathological observation was assayed at the degree of hepatic injury.Results: In the CISPLATIN receiving RATs, EECSL.S (40 and 80 mg/kg) and silymarin significantly decreased the levels of serum biomarkers of hepatic injury and total bilirubin and significantly elevated the levels of serum albumin and total proteins.In these RATs, EECSL.S and silymarin decreased the lipid peroxidation and elevated the levels of antioxidant enzymes in a dose dependent manner.Histopathologically, EECSL.S and silymarin ameliorated CISPLATIN-induced hepatic injuries and the changes were in agreement with biochemical findings.Conclusion: EECSL.S protects hepatic tissue against CISPLATIN-induced HEPATOTOXICITY in RATs due to its ANTI-OXIDANT properties.

Cites

References

No record.

Cite

APA: Copy

MOHAJERI, DARYOUSH, & DOUSTAR, YOUSEF. (2012). PROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF CROCUS SATIVUS L.(SAFFRON) STIGMA AGAINST CISPLATIN INDUCED HEPATOTOXICITY IN RATS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 21(4 (66)), 251-261. SID. https://sid.ir/paper/98879/en

Vancouver: Copy

MOHAJERI DARYOUSH, DOUSTAR YOUSEF. PROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF CROCUS SATIVUS L.(SAFFRON) STIGMA AGAINST CISPLATIN INDUCED HEPATOTOXICITY IN RATS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2012;21(4 (66)):251-261. Available from: https://sid.ir/paper/98879/en

IEEE: Copy

DARYOUSH MOHAJERI, and YOUSEF DOUSTAR, “PROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF CROCUS SATIVUS L.(SAFFRON) STIGMA AGAINST CISPLATIN INDUCED HEPATOTOXICITY IN RATS,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 21, no. 4 (66), pp. 251–261, 2012, [Online]. Available: https://sid.ir/paper/98879/en

Related Journal Papers