THE EFFECT OF SODIUM BUTYRATE, HISTONE DEACETYLASE INHIBITOR ON SPATIAL LEARNING AND MEMORY IN RAT MODEL OF CEREBRAL HYPOXIC-ISCHEMIA

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EDALATMANESH MOHAMMAD AMIN; SAHRAEIAN SAMIRA; RAFIEI SAMANEH

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Journal Paper

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Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2018 | Volume:28 | Issue:1 Page(s): 16-23

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Title

THE EFFECT OF SODIUM BUTYRATE, HISTONE DEACETYLASE INHIBITOR ON SPATIAL LEARNING AND MEMORY IN RAT MODEL OF CEREBRAL HYPOXIC-ISCHEMIA

Author(s)

EDALATMANESH MOHAMMAD AMIN | SAHRAEIAN SAMIRA | RAFIEI SAMANEH | Issue Writer Certificate

Keywords

HYPOXIA-ISCHEMIAQ1

HISTONE DEACETHYLASE INHIBITORSQ1

SPATIAL MEMORYQ2

MORRIS WATER MAZEQ2

RATQ2

Abstract

Background: Cerebral ischemic stroke is the third cause of death in developed countries and is one of the main causes of long-term disabilities. This study investigated the effect of sodium butyrate, as histone deacetylase inhibitor (HDAI), on spatial learning and memory in cerebral hypoxic ischemia (HI) model. Materials and methods: In this experimental study, fifty male RATs were divided into control, HI+Saline, HI+SB 0. 1, HI+SB 0. 3, and HI+SB 0. 6 groups. In order to induce HI model, after permanent left carotid artery closure, the RATs was placed in the hypoxic chamber (8% oxygen) for 1 hour. 24 hours after surgery, based on RATs' weight sodium butyrate was injected at doses of 0. 1, 0. 3 and 0. 6 mg/ kg as intra-peritoneal for 14 days. RATs in HI+Saline group were received normal saline for 14 days. SPATIAL MEMORY in these groups was studied by MORRIS WATER MAZE (MWM) test. Then, the hippocampal level of BDNF was measured using ELISA. Results: However, HI+Saline group had a longer latency time to find hidden platform in MWM test, the results indicated improved SPATIAL MEMORY or decreased latency time to find hidden platform in MWM in RATs received sodium butyrate. In spite of decreasing the hippocampal level of BDNF in the HI+Saline RATs, this factor significantly increased in SB-treated RATs. Conclusion: Sodium butyrate is able to improve spatial learning and memory in cerebral hypoxic ischemia model.

Cites

Neuroprotective Effect of Gallic Acid on Memory Deficit and Content of BDNF in Brain Entorhinal Cortex of Rat’ s Offspring in Uteroplacental Insufficiency Model

References

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APA: Copy

EDALATMANESH, MOHAMMAD AMIN, SAHRAEIAN, SAMIRA, & RAFIEI, SAMANEH. (2018). THE EFFECT OF SODIUM BUTYRATE, HISTONE DEACETYLASE INHIBITOR ON SPATIAL LEARNING AND MEMORY IN RAT MODEL OF CEREBRAL HYPOXIC-ISCHEMIA. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 28(1 ), 16-23. SID. https://sid.ir/paper/98914/en

Vancouver: Copy

EDALATMANESH MOHAMMAD AMIN, SAHRAEIAN SAMIRA, RAFIEI SAMANEH. THE EFFECT OF SODIUM BUTYRATE, HISTONE DEACETYLASE INHIBITOR ON SPATIAL LEARNING AND MEMORY IN RAT MODEL OF CEREBRAL HYPOXIC-ISCHEMIA. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2018;28(1 ):16-23. Available from: https://sid.ir/paper/98914/en

IEEE: Copy

MOHAMMAD AMIN EDALATMANESH, SAMIRA SAHRAEIAN, and SAMANEH RAFIEI, “THE EFFECT OF SODIUM BUTYRATE, HISTONE DEACETYLASE INHIBITOR ON SPATIAL LEARNING AND MEMORY IN RAT MODEL OF CEREBRAL HYPOXIC-ISCHEMIA,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 28, no. 1 , pp. 16–23, 2018, [Online]. Available: https://sid.ir/paper/98914/en

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