Background and Objective: The main goal of this research was “ The Relationship between Personnel’ s Blood Lead Concentration Parameter, Job Stress and Job-Burnout Parameters in Staff of a Battery Manufacturing Company” . Method: It was a descriptive and cross sectional investigation. The sample group (with age range 20-65) included 100 out of 200 staff who worked in the productive lines of company. They were selected randomly. Job Stress (Davies, 1991) and Maslach Job-Burnout (1981) questionnaires were used as tools. Also the lead concentration of whole blood was determined by using atomic absorption spectrometer. Findings: The results of Pearson correlation test showed that there are significant relationship between blood lead concentration with depersonalization and low performance of staff (P<0. 01, P<0. 05). There are significant relationship between stress related to jobs and job-burnout dimensions (P<0. 01). The results revealed that blood lead and job stress can predict depersonalization and weak performance of staff. Discussion and Conclusion: Many workers are in the exposure of chemical hazards like lead concentration simultaneously they are suffering from job stress and different types of pressures because of hard conditions of job in a battery manufacturing companies. These difficult conditions can lead them towards job-burnout (depersonalization and weak performance) too. It was recommended to the managers and engineers to control dust and fumes of lead pollution with respect to occupational health and safety in the workplaces. The management plans should be targeted the job related stress management and prevention of job burnout as well.