Accidental or intentional poisoning with Aluminum phosphide (ALP) is associated with severe complications such as metabolic acidosis, cardiac failure, and death. Previous animal experiments demonstrated that fresh-packed RBC is protective in an experimental model of ALP poisoning. The aim of this study was to assess the effect of fresh-packed RBC on survival in patients admitted to a referral hospital due to ALP poisoning in a randomized clinical trial. Eighty-two patients were admitted to Clinical Toxicology Unit at Baharloo Hospital due to acute ALP poisoning after approval by the Iranian Registry of Clinical Trials (registration reference: IRCT20180428039443N1). All patients received standard treatment, and forty-one of them received fresh-packed RBC. There was no significant difference between groups in the underlying characteristics, including vital signs and laboratory investigations. But interestingly, the mortality rate was meaningfully decreased (difference: 31. 7%, 95% CI: 0. 10-0. 52) in patients receiving fresh-packed RBC (10 deaths/31 survived,24. 4% mortality) in comparison to standard treatment patients (23 deaths/18 survived,56. 1% mortality). Furthermore, fresh-packed RBC substantially improved the GCS, systolic/diastolic blood pressure, ST changes, and pH 12-and-24 hours after admission. This study showed that fresh-packed RBC infusion alongside standard supportive treatment leads to a decrease in mortality rate,also, it provided evidence for a protective role of fresh-packed RBC in the management of patients with acute ALP poisoning.

Stabilizations and atomic level quadrupole coupling constant (CQ) properties have been investigated for grapheme-like monolayers (G–monolayers) of boron nitride (BN), boron phosphide (BP), aluminum nitride (AlN), and aluminum phosphide (ALP) structures. To this aim, density functional theory (DFT) calculations have been performed to optimize the model structures and also to evaluate the CQ parameters. The results of optimizations indicated that the formations, polarities, and semiconducting properties of BN G–monolayer are more favorable than other investigated G–monolayers. Moreover, the atomic level CQ parameters also indicated that the atoms at the tips of monolayers have the most activities among other atoms and different properties have been seen for the atoms at different positions of monolayers. Differences of electronegativities are also important for the magnitudes of CQ properties as could be seen by larger values of CQ parameters for B and Al atoms in the BN and AlN G–monolayers in comparison with BP and ALP G–monolayers.

Introduction & Objective:  Diabetes is a metabolic resulting from defects in insulin secretion and function. Pomegranate is a nutritional substance, used in traditional medicine to treat diabetes. In the current study we checked the treating effects of the pomegranate juice on diabetes and its side effects on liver. Thus, in the current study investigated the effects of pomegranate juice on liver enzymes (ALT, ALP, AST) in diabetic and non-diabetic rats.Material and Methods: In the current study, 90 adult  male Wistar rats weighing  200 to 220 g each were randomly selected and divided to five groups of control(without any intervention), sham (distilled water), experimental diabetic and non –diabetic1,2 and 3 groups (4cc of pomegranate juice (PJ)). Diabetes was induced in rats by intraperitionesl injection of 60 mg/kg of streptozotocin. In the experimental groups, rats were treated for 21days with a signal dose of pomegranate juice for each day. At the end of the day 21, a blood sample was taken from the experimental and control group and were measured the serum levels of liver enzymes (ALT, AST, ALP). The data were evaluated using ANOVA and LSD.Results: Results showed that pomegranate juice reduces significantly liver enzymes (ALT, AST, and ALP) in the diabetic group than in the control group and the control group had no significant effect.Conclusion: Pomegranate juice with flavonoid and antioxidant compounds and also due to decrease blood glucose levels causes enzymes of ALT, AST, and ALP in diabetic rats.

In Iran, herbal or chemical rice tablets containing ALP protect grains from pests. Deaths have been reported following both accidental and intentional exposure to aluminum phosphide. A 20-year-old woman who intentionally ingested a 3-gram ALP tablet and became poisoned is the primary focus of this case report. It outlines the successful management of a patient who had taken a rice tablet and suffered from acute cardiogenic shock, severe metabolic acidosis, and severe hypotension. This patient survived successfully despite the higher mortality rate due to cardiac and multi-organ problems from exposure to phosphine gas, particularly the rice tablet and cellular hypoxia. In addition to daily supportive therapies, an antioxidant regimen, glucose, insulin, and potassium (GIK), and prompt intubation to improve cardiac function assisted with the recovery.