Objectives: Abnormal uterine bleeding (AUB) is a disorder which adversely influences the social status and level of satisfaction in women with reproductive ages. Improving health-related quality of life (HRQL) is a precious goal in the treatment of AUB. The aim of this study was to evaluate the QOL in patients with AUB and the affecting factors. More precisely, this study attempted to assess which different aspects of QOL may be influenced by AUB. Materials and Methods: This cross-sectional study was performed on 152 women with AUB refereeing to our gynecology and obstetrics department of a tertiary center in Semnan, Iran in 2015-2016. The QOL was investigated in these women using Clinical History Assessment Tool (CHAT) and SF-36. Finally, the data were analyzed in SPSS-21 software and after performing Fisher exact test and K2 test, P < 0. 05 was considered to be significant. Results: In general, 152 patients were enrolled in our study. The results suggested that the QOL and level of life satisfaction were not changed according to the age, gender, matrimonial status, place of residence, occupation, education, body mass index, or the hemoglobin level in this group. However, menorrhagia significantly affected the dimensions of physical functioning, vitality and dynamism, social functioning, and pain and general health perception. Conclusions: Overall, women with AUB, especially those with menorrhagia, have extremely lower QOL than the others. By recognizing all contributing factors to the QOL in such women, it can be possible for gynecologists to help the women improve their diary functions and comfort levels. Nonetheless, more studies seem to be needed to evaluate these factors.