Background and Objectives: The interleaved approach has a long history of use in power electronics, particularly for high-power systems. The voltage and current stress in these applications exceed the tolerance limit of a power element. The present paper introduces an improved version of an interleaved boost converter, which uses voltage mode control. The objectives of this research are improvement in the interleaved boost converter’s performance in terms of the temporal parameters associated with settling duration, rising time, and overshoot.Methods: An improved PI controller (proportional integral controller) is used for adjusting the proposed converter’s output voltage. In the present work, the Grey Wolf Optimization algorithm with Aggregation function definition (GWO_AF) is utilized to adjust the free coefficients of the PI controller. In reality, the closed-loop dynamic performance and stability can be improved by designing and implementing an optimized PI controller.Results: The improvement of the freedom degree in the interleaved boost converter resulted from the existence of a few power switches in a parallel channel in the proposed circuit. An additional advantage of the interleaved boost converter, compared to the conventional one, is that it produces a lower output voltage ripple. Conclusion: The usage of multi-objective optimization algorithms in designing a PI controller can significantly improve the performance parameters of an interleaved boost converter. Also, our findings indicated the excellent stability of the proposed converter when connected to the network.

Background: Antithrombotic therapy, such as acetylsalicylic acid (ASA) and clopidogrel, may interfere with platelet Aggregation in thrombotic strokes. Therefore, a platelet Aggregation test is essential for monitoring therapy. A previous study observed a decrease in platelet Aggregation using antithrombotics with a manual LTA analyzer. Further research is required to compare this with an automatic tool to determine whether both instruments have similar detection capabilities.Methods: PPP and PRP samples were collected from 30 thrombotic stroke outpatients and 30 healthy controls. Platelet Aggregation tests were performed using ADP 5µM and Collagen 2µg/mL on both instruments, Chronolog® Model 490, and Sysmex® CS-2500. The tests were then analyzed using the Wilcoxon test for differences, the Spearman test for correlation, and the Bland-Altman analysis for agreement.Results: No differences were observed in MA values and numerical alignment between the two instruments for ADP and Collagen. If the MA result for the platelet Aggregation test on Chrono-log® Model 490 was high, it was likewise high on Sysmex CS-2500 and vice versa. Although the values of LP and Vel differed, the numbers for ADP and Collagen in both instruments were consistent.Conclusion: The comparison between both instruments indicates good agreement. Automated LTA demonstrates the same suitability as manual LTA and can be applied in clinical routines to assess platelet Aggregation function. Due to many variations in the pre-analytics stage that might affect the results, it is vital to standardize both the pre-analytics, analytics, and post-analytics stages to compare platelet Aggregation tests on the two instruments.