TWO NEW BIBR3 SUPRAMOLECULAR COMPLEXES, [BI(2-BPMP)BR2.06CL0.94] (1) AND [BI(4- H2BPMP)BR4.29CL0.71]·H2O (2) {2-BPMP = N,N’-BIS (2-PYRIDYLMETHYL) PIPERAZINE AND 4-BPMP = N,N’-BIS (4-PYRIDYLMETHYL) PIPERAZINE} WERE PREPARED BY REACTION OF BISMUTH (III) CHLORIDE AND POTASSIUM BROMIDE WITH TWO ORGANIC NITROGEN DONOR BASED LIGANDS UNDER THERMAL GRADIENT CONDITIONS USING THE BRANCHED TUBE METHOD. COMPOUNDS 1-2 WERE STRUCTURALLY CHARACTERIZED BY SINGLE-CRYSTAL X-RAY DIFFRACTION. IN THE MONOMERIC COMPLEX 1 THE BISMUTH ATOMS ARE COORDINATED BY TWO PYRIDYL AND PIPERAZINE NITROGEN ATOMS OF A 2-BPMP LIGAND, AND BY THREE HALOGEN ATOMS. COMPOUND 2 IS ALSO MONOMERIC BUT IS BONDED TO ONLY ONE PYRIDYL NITROGEN ATOM. IN BOTH COMPOUNDS EXTENSIVE HYDROGEN-BONDING INTERACTIONS LEAD TO THE FORMATION OF SUPRAMOLECULAR NETWORKS, IN COMPOUND 2 THE HYDROGEN BONDS ARE AUGMENTED BY P-P STACKING INTERACTIONS. THE THERMAL STABILITIES OF BOTH COMPOUNDS WERE STUDIED BY THERMAL GRAVIMETRIC (TG) AND DIFFERENTIAL THERMAL ANALYSES (DTA). THERMAL DECOMPOSITION OF THE NANO SIZED PARTICLES OF 1,2 IN AIR ATMOSPHERE PRODUCED BIOBR NANOPARTICLES.

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BACKGROUND: MEDICAL IMAGING BY X-RAY IS ONE OF THE DIAGNOSTIC METHODS IN GYNECOLOGIC DISEASES. IN THESE IMAGING METHODS, SENSITIVE ORGANS SUCH AS BREAST DUE TO ANATOMICAL POSITION AND RECEIVING HIGH RADIATION DOSE, BREAST CANCER RISK IS ENCOUNTERED. THEREFORE, FOR PROTECTION OF BREAST USING RADIATION SHIELD WAS PROPOSED.IN THIS STUDY, PREVENTION EFFECT OF BISMUTH SILICON SHIELD ON THE BREAST CANCER RISK AT CHEST CT WAS STUDIED...

THE ORGAN OPLATINUM (IV) COMPLEXES [PT(X)2ME2(TBU2BPY)] AND [PTME(X)2(PPY)PPH3] (TBU2BPY = 4,4-DI-TERTBUTYL-2,2-BIPYRIDINE, PPY = DEPROTONATED 2–PHENYLPYRIDINE AND X = CL, BR, I) ARE SYNTHESIZED BY THE REACTION OF [PTME2(TBU2BPY)] AND [PTME(PPY)PPH3] WITH BISMUTH TRIHALIDES AS A SOURCE OF HALIDE INSTEAD OF NO FAVORABLE REAGENTS X2. THE REACTION OF [PTME(PPY)PPH3] WITH BII3 WAS MONITORED USING UV-VIS SPECTROSCOPY AND A MECHANISM FOR ACTIVATION OF BI-X BONDS IS PROPOSED. A THEORETICAL STUDY IS PRESENTED AND SHOWN THAT THE OXIDATIVE ADDITION OF EITHER OF BIX3 TO THE PT(II) COMPLEXES IS ENDERGONIC FOR ALL BISMUTH HALIDES.IN A COMPARATIVE WORK, THE REACTION [PTME2(P–P)] COMPLEXES, P-P=DPPM OR DPPE, WITH BISMUTH TRIHALIDES WAS STUDIED AND PROPOSED TO PROCEED THROUGH BISMUTH–HALIDE OXIDATIVE ADDITION AND BISMUTH–CARBON REDUCTIVE ELIMINATION REACTIONS TO YIELD A MIXTURE OF THE PLATINUM (II) COMPLEXES [PTMEX(P–P)] AND [PT(X)2(P–P)]. THESE REACTIONS, WHICH ARE THE FIRST EXAMPLES OF ADDITION OF BISMUTH TRIHALIDES TO ORGAN OPLATINUM (II) COMPLEXES, WERE MONITORED USING 31P NMR AND UV-VIS SPECTROSCOPY AND A MECHANISM IS PROPOSED FOR THE REACTION. THE NATURE OF HALIDE HAS AN EFFECT ON THE RATES OF OXIDATIVE ADDITION OF BIX3 TO PT (II) COMPLEXES; THE PROCESS BECOMES SLOWER AS THE HALIDE BECOMES LARGER.

Colloidal bismuth salysilate and some of the other insoluble bismuth salts are effective drugs in treatment of ulcer of stomach and duodenum and also diarrhea. One of the bismuth effects is the effect on the gastrointestinal absorption of tetrasyc- line, calcium and specially Iran. Content of food, and decreasing the gastrointestinal absorption of these compounds. The reason for that is well known as chelating of bismuth with these compounds. Even though bismuth has medical uses, it is reported that have many side effects on patients with chronic gastrointestinal problems,causing psychological effects with usage of bismuth as reported in Australia  & France. These patients are suffering from dysfunctional muscle movement, depression, nervousness fallowing with some mental side effects. Tremors dysphasia, the aim of the study was to investigate the toxicity effects of bismuth. For this reason, during two short periods of 5 and 15 days, and two long periods of 30 and 60 days, different amounts of bismuth nitrate have injected in prêt mum to male rats and factors related to Iron metabolism were analyzed. The results obtained in this project show that the amount of ceruloplasmin between 12.98 and 19.7% and the amount of serum iron show the minimum decrease rather than the control group which is 10.9% and 27.4% and hemoglobin shows the minimum 19.27% and 6.8% decrease on the control group and the decrease of hematocrit of 14.65 and 19.7% and TIBC 5.09% and 16.3% show increase rather than control group, on the other hand, it shows the minimum decrease of serum copper in comparison with control group which is 10.45% and 27.45% and it relates to daily prescribed bismuth nitrate of 80 µmol/kg body weight, during 15days and 50 µmol/kg body weight during 30 days in order, rather than control group. The long term usage of bismuth compounds results in disturbance in Iran Metabolism and causes anemia.