Non-COMMUNICABLE DISEASES (NCDs) are the leading cause of death and disease burden globally, cardiovascular DISEASES (CVDs) account for the major part of death related to NCDs followed by different types of cancer, chronic obstructive pulmonary disease (COPD), and diabetes. As the World Health Organization (WHO) and the United Nations have announced a 25% reduction in mortality of NCDs by 2025, different communities need to adopt preventive strategies for achieving this goal. Personalized medicine approach as a predictive and preventive strategy aims for a better therapeutic goal to the patients to maximize benefits and reduce harms. The clinical benefits of this approach are already realized in cancer targeted therapy, and its impact on other conditions needs more studies in different societies. In this review, we essentially describe the concept of personalized (or precision) medicine in association with NCDs and the future of precision medicine in prediction, prevention, and personalized treatment.

Non-COMMUNICABLE DISEASES as a leading cause of death have a surveillance system in most countries. This is disturbed by the emergence of coronavirus disease-2019 (COVID-19) in December 2019. In this regard, health system managers at decision-making levels tried to overcome this problem. Therefore, strategies to deal with this issue and bring the surveillance system to an ideal state were proposed and considered.

Background: Non-COMMUNICABLE DISEASES cause more than 60% of disease burden and 70% death by 2020. NCD risk factors surveillance system is a global strategy to combat with this problem in the world. It has been established since 2004 in Iran.Methods: The first national surveillance risk factors of Non-COMMUNICABLE disease (SURFNCD) run as a cross sectional study on 89000 populations by applying who stepwise approach in January and February 2005. Result: The prevalence of common risk factors were 14.2 current smokers, 32.5% did exercise at least 10 minutes in their free time in ages 15-64 yr, 7.7 diabetics and 25.2 hypertensive in ages 25-64 yr. Obesity, overweight and hypercholesterolemia were 14.8, 28.6 and 15.1, respectively in ages 15-64 yr.Conclusion: Implementation of this system is one of the main concerns of Iranian prototype surveillance system and international concerned bodies such as World Health Organization. Multi-pronged policy and programmatic interventions promoting for maximum effectiveness are needed to conduct.