Introduction: Cardiac toxicity induced by chemotherapy in patients with various malignancies can lead to serious cardiovascular COMPLICATIONS that are harmful to the patient. Goal: Determination of cardiovascular COMPLICATIONS of chemotherapy Method: Study and research on internet and review of literature Introducing the problem: Cardiovascular COMPLICATIONS of chemotherapy induced cardiac toxicity are due to administration of chemotherapy drugs will be created. Cardiac toxicity induced by chemotherapy can be asymptomatic or may manifest as transient arrhythmias to fatal cardiomyopathy resulting from permanent left ventricular dysfunction and may occur acutely during treatment or years later and varies for different chemotherapy drugs. Some of these Cardiac COMPLICATIONS are include Angina, arrhythmias, cardiogenic shock, cardiomyopathy, deep venous thromboembolism, edema, effusion, endomyocardial fibrosis, heart block, hypertension and hypotension, ischemia/infarction, left ventricular dysfunction, myocarditis/ pericarditis, possible cardiac toxicity and vasospasm. The signs and symptoms of cardiotoxicity vary widely. Signs of cardiac dysfunction may include changes in blood pressure or heart rate, irregular heart rhythms, murmurs, carotid bruits, distended jugular veins, decreased pulses, edema, and changes in skin color. The most common symptoms of cardiac problems associated with cardiotoxicity are pain, dyspnea, weight gain, edema, weakness, fatigue, palpitations, dizziness, syncope and swelling of an extremity with deep venous thromboembolism. Conclusion: Patients with cardiovascular COMPLICATIONS of chemotherapy and their family members should be educated about the signs and symptoms of cardiotoxicities and they should notify health care personnel when signs or symptoms of these conditions occur.

Diabetic vascular COMPLICATIONS (DVC) influence several vital organ systems including cardiovascular, renal, ocular and nervous systems making it a major public health problem. Although extensive researches were performed in this field, the exact mechanisms responsible for these organ damages in diabetes remain obscure. Several metabolic disturbances have been involved in its complication and change in genes associated with these pathways occurred. Gene expression to produce a biologically active protein can be controlled by transcriptional and translational alteration on the head of genes without change in nucleotide composition. These epigenetic adjustments are steady, but possibly reversible and can be transmitted to future generation. Gene expression can be regulated by three epigenetic mechanisms including DNA methylation, histone modifications and noncoding microRNAs (miRNAs) activity. Epigenetic studies must be directed to better realize the role of epigenetic changes to the etiology of DVC and knowledge of epigenetic would play a pivotal role in the application of individualized medicine. Application and development of high technology sequencing combined with more sensitive and advanced methodologies for epigenome studying help to determine specific epigenetic events that stimulate gene responses in patients with diabetes mellitus.

Objectives: This study aimed to evaluate the frequency of episiotomy and its early COMPLICATIONS in natural vaginal delivery in the maternity ward of Ali Ibn Abitaleb (AS) Hospital in Zahedan from 2014-2016. Methods: In this cross-sectional study, which was conducted in 2017, the archives of women who gave birth between 2014-2016 were reviewed. Data were collected using information forms and analyzed by SPSS software. Results: Of 418womenwere reviewed, the episiotomy rate was 54. 5%; there was a significant association between parity and mother age with episiotomy rate. Moreover, 24-hour pain frequency, perineal rupture rate, hematoma rate was significantly higher in the episiotomy group. First-and fifth-minute Apgar of the neonates in the episiotomy group was significantly lower. Conclusions: In overall, the episiotomy rate was 54. 5%, and there was a significant association between parity and mother age with episiotomy rate.