Background: An important application in health care SYSTEM is COMPUTERIZED PHYSICIAN ORDER ENTRY SYSTEM (CPOE) which improves the quality of patient’ s care. Given that the users’ satisfaction is necessary in predicting the success of a SYSTEM, this study aimed to evaluate the satisfaction of CPOE users in Namazi Hospital. Methods: This cross-sectional study was conducted as a descriptive-analytical research three months after CPOE implementation in Namazi Hospital. The study population consisted of all PHYSICIANs and nurses in General Intensive care Unit (ICU), which included 14 PHYSICIANs and 26 nurses who had been working with CPOE SYSTEM. A standard questionnaire was applied for data gathering; its validity and reliability was confirmed in the study (α =0. 84). The data were processed by SPSS 21 software and appropriate statistical tests including T test, One-way Anova and Chi-square tests were used. Results: Overall, the satisfaction of PHYSICIANs and nurses about the CPOE SYSTEMs was moderate (4. 83± 1. 99). Although the PHYSICIAN’ s satisfaction score was 5. 30± 1. 54, which was greater than that of nurses (4. 56± 2. 19), this differences was not significant (P>0. 05). Results also showed a significant relationship between the user satisfaction score and age and gender of the participants (P=0. 001, P=0. 006) respectively. A significant relationship was found between the CPOE user friendliness and age (P=0. 05). Conclusion: Overall, there is a relative satisfaction among the PHYSICIANs and nurses about CPOE in Namazi hospital. Hospital managers could accelerate the use of CPOE in hospitals. It is suggested that the challenges of the SYSTEM should be examined in future studies.