Osteoporosis is a disease of high prevalence with increased bone loss. It has potential public health threat and that the health authorities had taken several measures for its control. In recent years, considerable attention has been given to physiopathology of osteoporosis. Oxidative stress has been proved to be involved in bone resorption. Oxidative stress occurs when balance between oxidants and biochemical antioxidants is disrupted because of excess reactive oxygen species.Thus, we measured Catalase activity, as one of the marker of stress oxidative, in 138 women. Participants were selected by inclusion and exclusion criteria from those who were referred to Jamie Clinic in Tehran for BMD evaluation. Catalase antioxidant activity was 262.01±44.70 k/gHb in the group of subjects with osteoporosis in comparison with the group of healthy subjects, 273.77±46.92 k/gHb. The results show that Catalase activity in patients with bone deficiency was less than in the control group, though it was not significant. This difference was more between control and patients group with more acute disease (T score -1.7) than patients group with milder disease (T score<-1).The results show that it may be useful to monitor osteoporosis in the more expanded sample size to obtain more definition results.

Background: Keratoconus (KC) is a degenerative eye disease which results from thinning of the cornea and causes vision distortion. Oxidative stress damage to KC corneas may be because of the failure of corneas to process reactive oxygen species which leads to corneal thinning and loss of vision. Genetic variants in antioxi-dant defense genes such as Catalase (CAT) and glutathione peroxidase (GPX) can decrease antioxidant capacity or increase oxidative stress and alter the risk of KC in patients. We investigated and evaluated the effects of single nucleotide polymorphisms in CAT, GPX-1 on the risk of KC in an Iranian population sample. Methods: This case-control study was performed on 140 patients with KC and 150 healthy control subjects in a sample of Iranian population from Zahedan, southern Iran in 2015. Genotyping of CAT rs7943316 and GPX-1 rs1050450 polymorphisms was done using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) method. Results: CAT rs7943316 A/T, AA genotype and A allele have a protective role against disease (OR =0. 28, 95% CI =0. 13-0. 61, P=0. 001 and OR = 0. 50, 95% CI =0. 35-0. 72, P=0. 0001, respectively) and decreased the risk of KC. Moreover, GPX-1 rs1050450 T allele increased the risk of KC in comparison with C allele (OR = 1. 42, 95% CI = 1. 01-2. 03, P=0. 03). Conclusion: CAT rs7943316 A/T, AA genotype, and A allele decreased the risk of KC. Moreover, in GPX-1 rs1050450 C/T polymorphism, T allele was associated with an increased risk of KC in our population.